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Vol. 46. Issue 1.
Pages 39-44 (January - February 2018)
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Vol. 46. Issue 1.
Pages 39-44 (January - February 2018)
Original Article
DOI: 10.1016/j.aller.2017.03.005
Correlation between serum vitamin D status and immunological changes in children affected by gastrointestinal food allergy
H. Guo1, Y. Zheng1, X. Cai, H. Yang, Y. Zhang, L. Hao, Y. Jin, G. Yang
Corresponding author

Corresponding author.
Gastroenterology Unit, Nanjing Children's Hospital Affiliated with Nanjing Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China
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Figures (1)
Tables (3)
Table 1. Characteristics of GFA children and control group.
Table 2. Comparisons of children with GFA based on serum 25OHD.
Table 3. Comparisons of GFA children with increased total IgE based on serum 25OHD.
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Low vitamin D status is linked to increased incidence of food allergy and intestinal inflammation. Whether vitamin D status is associated with immunological changes in children with gastrointestinal food allergy (GFA) remains unclear.


Forty-nine GFA children (aged 2–11 years old) were enrolled in this study. Serum 25-hydroxyvitamin D (25OHD) level, total immunoglobulin E (IgE), specific IgE against allergens, circulating regulatory T lymphocytes (Tregs), and blood eosinophil numbers were measured.


Levels of serum 25OHD in the GFA children ranged 35.5–156.4nmol/L, with a mean value similar to that of the healthy controls. Compared to those with normal 25OHD (≥75nmol/L), GFA children with low 25OHD (<75nmol/L) had increased total IgE (84% vs. 54%, P<0.05), persistent blood eosinophilia (56% vs. 25%, P<0.05), and delayed resolution of symptoms after food allergen elimination (odds ratio 3.51, 95% CI 1.00–12.36, P<0.05). Among the GFA children with elevated total IgE, those with low 25OHD had lower circulatory Tregs (8.79±2.4% vs. 10.21±1.37%, P<0.05), higher total IgE (1197.5±1209.8 vs. 418.5±304.6kU/L, P<0.05), and persistent eosinophilia (0.61±0.52 vs. 0.31±0.15×109cells/L, P<0.05) compared to those with normal 25OHD. In addition, serum 25OHD concentrations inversely correlated with total IgE (R=−0.434, P<0.05), and positively with Treg population (R=0.356, P<0.05).


Low serum vitamin D status correlates with stronger allergic immune response in GFA children.

Gastrointestinal food allergy
Regulatory T cells
Total immunoglobulin E
Vitamin D


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