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Vol. 43. Issue 3.
Pages 304-325 (May - June 2015)
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Vol. 43. Issue 3.
Pages 304-325 (May - June 2015)
Position Paper
DOI: 10.1016/j.aller.2015.01.004
Consensus document on the approach to children with allergic reactions after vaccination or allergy to vaccine components
Luis A. Echeverría-Zudairea,
Corresponding author

Corresponding author.
, Luis Ortigosa-del Castillob, Elena Alonso-Lebreroc, Francisco J. Álvarez-Garcíad, Nuria Cortés-Álvareze, Nuria García-Sánchezf, Antonio Martorell-Aragonésg
a Unidad de Alergia y Neumología Pediátrica, Servicio de Pediatría, Hospital Universitario Severo Ochoa, Leganés, Madrid, Spain
b Servicio de Pediatría, Hospital Universitario Ntra. Sra. de Candelaria (HUNSC), Santa Cruz de Tenerife, Spain
c Servicio de Alergia, Hospital Materno-Infantil Gregorio Marañón, Madrid, Spain
d Centro de Salud de Llanera, Llanera, Asturias, Spain
e Unidad de Alergia Infantil, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona, Spain
f Centro de Salud “Delicias Sur”, Zaragoza, Spain
g Unidad de Alergología, Hospital General Universitario, Valencia, Spain
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Figures (3)
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Tables (5)
Table 1. Available vaccines and corresponding adjuvants (latest revision: April 2014).
Table 2. Questionnaire prior to vaccination.
Table 3. Clinical criteria for the diagnosis of anaphylaxis.10
Table 4. Components with allergenic capacity among vaccines available in Spain (latest revision: April 2014).
Table 5. Vaccine protective antibody (Ab IgG) levels.28
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Vaccinations are one of the main public health tools for the control of vaccine-preventable diseases. If a child is identified as having had an allergic reaction to a vaccine, subsequent immunisations will probably be suspended – with the risks such a decision implies. The incidence of severe allergic reactions is very low, ranging between 0.5 and 1 cases/100,000 doses. Rather than the vaccine antigens as such, the causes of allergic reactions to vaccines are often residual protein components of the manufacturing process such as gelatine or egg, and less commonly yeasts or latex. Most vaccine reactions are mild and circumscribed to the injection site; although in some cases severe anaphylactic reactions can be observed. If an immediate-type allergic reaction is suspected at vaccination, or if a child with allergy to some of the vaccine components is scheduled for vaccination, a correct diagnosis of the possible allergic process must be made. The usual vaccine components must be known in order to determine whether vaccination can be safely performed.

Vaccines allergy
Delayed reactions


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