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Inicio Allergologia et Immunopathologia Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-...
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Vol. 45. Issue 4.
Pages 350-355 (July - August 2017)
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Vol. 45. Issue 4.
Pages 350-355 (July - August 2017)
Original Article
DOI: 10.1016/j.aller.2016.10.007
Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model
C. Zhao, S. Yu
Corresponding author

Corresponding author.
, J. Li, W. Xu, R. Ge
Department of Otolaryngology, Tongji Hospital, Tongji University, Shanghai 200065, China
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Medical gas hydrogen (H2) has a special role in airway inflammation; however, the effect of H2 on allergic rhinitis (AR) remains unclear. This study explored the possible roles of H2 on the pathogenesis of AR and observed the influences of H2 on cytokines IL-4 and IL-13.


An AR guinea pig model was established by nasal ovalbumin sensitisation. Eighteen guinea pigs were divided into three groups, namely, saline control, AR-sensitised, and hydrogen-rich saline (HRS)-treated groups, with each group having six guinea pigs. The frequencies of sneezing and scratching were recorded. The IgE level and cytokine (IL-4 and IL-13) levels in the serum were measured. The expression levels of IL-4 and IL-13 mRNA and protein in the nasal mucosa were also determined by real-time reverse transcriptase–polymerase chain reaction and Western blot. We also observed the infiltration of cytokine (IL-4 and IL-13) in nasal mucosa by immunofluorescence.


The frequencies of sneezing and scratching, as well as the levels of IgE, IL-4, and IL-13, in the serum were higher in the AR group than in the control group (p<0.01), whereas all these parameters were decreased significantly after HRS treatment (p<0.05). The expression levels of IL-4 and IL-13 mRNA and protein in the nasal mucosa were also lower in guinea pigs treated with HRS than those in the AR group (p<0.05).


HRS could affect anti-inflammation in AR and decreased the expression of IL-4 and IL-13.

Allergic rhinitis
Hydrogen-rich saline


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