Buscar en
Allergologia et Immunopathologia
Toda la web
Inicio Allergologia et Immunopathologia Bronchopulmonary dysplasia as a risk factor for asthma in school children and ad...
Journal Information
Vol. 46. Issue 1.
Pages 87-98 (January - February 2018)
Download PDF
More article options
Vol. 46. Issue 1.
Pages 87-98 (January - February 2018)
DOI: 10.1016/j.aller.2017.02.004
Bronchopulmonary dysplasia as a risk factor for asthma in school children and adolescents: A systematic review
S. Pérez Tarazonaa,
Corresponding author

Corresponding author.
, P. Solano Galánb, E. Bartoll Alguacilb, J. Alfonso Diegoc
a Division of Neonatology, University & Polytechnic Hospital La Fe, Valencia, Spain
b Pediatric Pulmonology and Allergy Unit, University & Polytechnic Hospital La Fe, Valencia, Spain
c Pediatric Pulmonology and Allergy Unit, University Hospital La Ribera, Alzira, Valencia, Spain
Article information
Full Text
Download PDF
Figures (1)
Tables (4)
Table 1. Association between BPD and asthma in school-children and adolescents. Summary of the studies included in the review.
Table 2. Diagnostic criteria of BPD used in the selected studies.
Table 3. Diagnostic criteria of asthma used in the selected studies.
Table 4. Quality assessment tool for observational cohort and cross-sectional studies.13
Show moreShow less

Bronchopulmonary dysplasia (BPD) is a chronic lung disease that mainly affects extremely pre-term infants, and remains the most common complication of prematurity. Several studies have shown that prematurity predisposes to the development of asthma in school children and adolescents. Nevertheless, it is not clear to what extent a history of BPD involves an additional risk.


A systematic review of studies assessing the association between BPD and asthma in school-children and adolescents was made. A literature search was carried out in the MEDLINE and EMBASE databases to retrieve articles published between 1 January 2000 and 31 August 2016.


A total of 17 studies comprising 7433 patients were included in the review. There was considerable heterogeneity in the definitions of BPD and asthma among studies. Overall, the prevalence of asthma was higher in children and adolescents with a history of prematurity and BPD compared with those who did not develop BPD. However, in only one of the studies did this difference reach statistical significance. The main limitation of this review was potential bias due to the lack of adjustment for confounding factors between exposure (BPD) and outcome (asthma) in most of the studies.


Based on the studies reviewed, it cannot be argued that BPD, as an independent factor of prematurity, increases the risk of asthma defined by clinical parameters in school-children and adolescents. Further studies of greater methodological quality and homogeneous diagnostic criteria of BPD and asthma are needed for improved assessment of this association.

Bronchopulmonary dysplasia
Very low birth weight


These are the options to access the full texts of the publication Allergologia et Immunopathologia

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Allergologia et Immunopathologia

Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.