Buscar en
Allergologia et Immunopathologia
Toda la web
Inicio Allergologia et Immunopathologia Asthma diagnosis in infants and preschool children: a systematic review of clini...
Journal Information
Vol. 47. Issue 2.
Pages 107-121 (March - April 2019)
Download PDF
More article options
Vol. 47. Issue 2.
Pages 107-121 (March - April 2019)
Original Article
DOI: 10.1016/j.aller.2018.05.002
Asthma diagnosis in infants and preschool children: a systematic review of clinical guidelines
L. Morala,
Corresponding author

Corresponding author.
, G. Vizmanosb, J. Torres-Borregoc, M. Praena-Crespod, M. Tortajada-Girbése, F.J. Pellegrinif, Ó. Asensiog
a Pediatric Allergy and Respiratory Unit, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL - FISABIO Foundation), Alicante, Spain
b Centre Mèdic i Quirúrgic, Escaldes-Engordany, Andorra
c Pediatric Allergy and Respiratory Unit, Children's University Hospital Reina Sofia and The Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain
d Centro de Salud La Candelaria, Departamento de Farmacología, Pediatría y Radiología, Universidad de Sevilla, Sevilla, Spain
e Pediatric Allergy and Pulmology Unit, Dr. Peset University Hospital, Valencia, Spain and Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain
f Centro de Salud de Pizarrales, Salamanca, Spain
g Parc Taulí Hospital Universitario, Sabadell, Spain
Article information
Full Text
Download PDF
Figures (1)
Tables (2)
Table 1. Key questions selected for the systematic review of the concept and diagnosis of asthma in children under six years of age in clinical guidelines on asthma.
Table 2. Guidelines selected for offering information referred to the concept or diagnosis of asthma in childhood, including the first years of life (infants and preschool children), and their answers to the key questions.
Show moreShow less
Background and aim

The definition and diagnosis of asthma are the subject of controversy that is particularly intense in the case of individuals in the first years of life, due to reasons such as the difficulty of performing objective pulmonary function tests or the high frequency with which the symptoms subside in the course of childhood. Since there is no consensus regarding the diagnosis of asthma in preschool children, a systematic review has been carried out.

Materials and methods

A systematic search was made of the clinical guidelines published in the last 10 years and containing information referred to the concept or diagnosis of asthma in childhood – including the first years of life (infants and preschool children). A series of key questions were established, and each selected guide was analyzed in search of answers to those questions. The review protocol was registered in the international prospective register of systematic reviews (PROSPERO), with registration number CRD42017074872.


Twenty-one clinical guidelines were selected: 10 general guides (children and adults), eight pediatric guides and three guides focusing on preschool children. The immense majority accepted that asthma can be diagnosed from the first years of life, without requiring pulmonary function tests or other complementary techniques. The response to treatment and the exclusion of other alternative diagnoses are key elements for establishing the diagnosis. Only one of the guides denied the possibility of diagnosing asthma in preschool children.


There is generalized although not unanimous agreement that asthma can be diagnosed in preschool children.

Systematic review
Preschool children


These are the options to access the full texts of the publication Allergologia et Immunopathologia

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Allergologia et Immunopathologia

Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.