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Allergologia et Immunopathologia
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Vol. 48. Issue 5.
Pages 450-457 (September - October 2020)
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Vol. 48. Issue 5.
Pages 450-457 (September - October 2020)
Original Article
DOI: 10.1016/j.aller.2019.12.012
Asthma, allergic sensitization and lung function in sickle cell disease
Andrea Angela, Gustavo Falbo Wandalsenb,
Corresponding author

Corresponding author.
, Dirceu Soléb, Fernanda C. Lanzac, Carolina L.N. Cobrad, Cintia Johnstond, Josefina Aparecida Pellegrini Bragaa
a Division of Hematology, Department of Pediatrics, Federal University of São Paulo (UNIFESP), Brazil
b Division of Allergy and Clinical Immunology, Department of Pediatrics, Federal University of São Paulo (UNIFESP), Rua dos Otonis 725, 04025-002 São Paulo-SP, Brazil
c University Nove de julho (UNINOVE), Brazil
d Hospital São Paulo-Division of Pediatrics, Brazil
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Figures (2)
Tables (3)
Table 1. Demographics and lab results for the sickle cell disease (SCD) group and control group (CG).
Table 2. Asthma and respiratory outcomes (ISAAC questionnaire complemented with anamnesis) for sickle cell disease (SCD) patients and the control group (CG).
Table 3. Values of the spirometry parameters for the sickle cell disease (SCD) patients and control group (CG).
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Pulmonary disease is a frequent acute and chronic manifestation in sickle cell disease (SCD), presenting high morbidity and mortality.


To identify the prevalence and association of asthma, allergic sensitization and altered pulmonary function in patients with SCD (SS and Sβo).


A single-center, cross-sectional study was conducted, in which 70 patients with SCD and 44 controls, aged six to 18 years, responded to the questionnaire of the International Study of Asthma and Allergies in Childhood (ISAAC), complemented with an anamnesis regarding the associated clinical outcomes. All patients underwent immediate hypersensitivity skin tests with aeroallergens and a pulmonary function evaluation (spirometry). Regarding the statistical analysis, parametric and non-parametric methods were used, depending on the variables studied. Tests were considered significant when p<0.05.


There was no significant difference between the patients and controls regarding the prevalence of asthma and allergic sensitization (p>0.05). The number of occurrences of acute chest syndrome per patient per year was significantly higher for asthmatic patients than for non-asthmatic patients (p=0.04). Obstructive pulmonary function occurred in 30.9% of the patients and in 5.4% of the controls, and restrictive pulmonary function occurred in 5.5% of the patients and 5.4% of the controls. Asthma and wheezing in the last 12months had significant associations with obstructive pulmonary function (p=0.014 and p=0.027, respectively).


The occurrence of asthma, allergic sensitization and alteration in lung function in patients with SCD reinforces the importance of routine monitoring of these diagnoses, which allows for early treatment and prevention of the evolution of pulmonary disease in adulthood.

Sickle cell disease
Allergic sensitization
Lung function


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