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Inicio Allergologia et Immunopathologia Association between ADAM33 S2 and V4 polymorphisms and susceptibility to allergi...
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Vol. 44. Issue 2.
Pages 170-176 (March - April 2016)
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Vol. 44. Issue 2.
Pages 170-176 (March - April 2016)
Original Article
DOI: 10.1016/j.aller.2015.05.013
Association between ADAM33 S2 and V4 polymorphisms and susceptibility to allergic rhinitis: A meta-analysis
Zewen Lia,
Corresponding author

Corresponding author.
, Fubo Yana, Zhimin Yangb, Jie Zhoua, Yingchao Chena, Zhuhua Dingb
a Department of Otolaryngology, The Central Hospital of Xiaogan, Tongji Medical College, Huazhong University of Science Technology, Xiaogan, Hubei, China
b Department of Otolaryngology, The First People's Hospital of Xiaogan, Zhongnan Hospital of Wuhan University, Xiaogan, Hubei, China
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Tables (3)
Table 1. Characteristics of studies included in the meta-analysis.
Table 2. Analysis of the association between the ADAM33 S2 and V4 polymorphisms and AR.
Table 3. Analysis of the association between the ADAM33 T+1, T1 and T2 polymorphisms and AR.
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It has been reported that ADAM33 (a disintegrin and metalloproteinase domain 33) polymorphisms might be associated with susceptibility to allergic rhinitis (AR).


Owing to mixed and inconclusive results, we conducted a meta-analysis to systematically summarise and clarify the association between ADAM33 S2, V4, T1, T2 and T+1 polymorphisms and AR risk.


A systematic search of studies on the association of ADAM33 polymorphisms with susceptibility to AR was conducted in Pubmed and Embase. A total of five case–control studies with 1251 patients and 1634 controls were included. Meta-analysis indicated an association between the ADAM33 S2 and AR in allele comparison (G/C:OR=1.40, 95% CI 1.08–1.82, P=0.012), heterozygote comparison (CG/CC:OR=1.24, 95% CI 1.04–1.48, P=0.015), and dominant comparison (CG+GG/CC:OR=1.39, 95% CI 1.05–1.85, P=0.023). The meta-analysis also revealed an association between the ADAM33 V4 and AR in allele comparison (G/C:OR=1.67, 95% CI 1.01–2.75, P=0.044). However, no association was found between AR and the ADAM33 T1, T2 and T+1 polymorphisms in any gene model comparison.


This meta-analysis demonstrates that the ADAM33 S2 and V4 polymorphisms confer susceptibility to AR. However, these results should be interpreted with caution due to limited sample and heterogeneity. Large-scale and well-designed studies are needed to validate our findings.

Allergic rhinitis


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