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Vol. 43. Issue 4.
Pages 353-360 (July - August 2015)
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Vol. 43. Issue 4.
Pages 353-360 (July - August 2015)
Original Article
DOI: 10.1016/j.aller.2014.03.002
Antioxidant foods consumption and childhood asthma and other allergic diseases: The Greek cohorts of the ISAAC II survey
A. Papadopouloua,
Corresponding author

Corresponding author.
, D.B. Panagiotakosb, E. Hatziagorouc, G. Antonogeorgosb, V.N. Matzioud, J.N. Tsanakasc, C. Gratzioue, S. Tsabourif, K.N. Priftisf
a Asthma and Allergy Pediatric Unit, “KAT” General Hospital, Kifisia, Greece
b Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
c 3rd Department of Paediatrics, School of Medicine, Aristoteleio University of Thessaloniki, Thessaloniki, Greece
d Department of Nursing, University of Athens, Greece
e Evgenidio Hospital, School of Medicine, University of Athens, Athens, Greece
f Paediatric Pulmonology and Allergy Units, 3rd Department of Paediatrics, “Attikon” Hospital, School of Medicine, University of Athens, Greece
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Tables (4)
Table 1. Social and environmental characteristics of the 9–10-year-old children that participated in the study.
Table 2. Prevalence (95% confidence interval) of asthma symptoms in 9–10-year-old children that participated in the Greek cohorts of the phase II ISAAC survey.
Table 3. Weekly eating habits (times per week) and asthma symptoms prevalence in the two major cities in Greece, Athens and Thessaloniki.
Table 4. Results from multiple logistic regression models that evaluated lifetime asthma symptoms prevalence in 9–10-year-old children from the two major Greek cities, Athens and Thessaloniki.
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Antioxidant intake changes have been implicated with the increase in asthma and allergies outcomes, but no clear association has been revealed. In this cross sectional study, the overall effect of antioxidants on asthma and allergic diseases was studied.


Data from the cohorts of the phase II ISAAC survey (2023 children 9–10 years old) in two metropolitan Greek cities were analysed. Using a semi-quantitative food frequency questionnaire, an Antioxidant Eating Index (AEI, range 0–6) was created with the pro-antioxidant (vegetables, fruits, fresh juice, fish) and the non-antioxidant (meat, burgers) food intake and was evaluated with allergic diseases. Higher values of the score suggest closer to an “antioxidant” and lesser to a “saturated fatty” diet.


Prevalence of lifetime and current asthma, current rhinitis and sensitisation were higher in Thessaloniki compared to Athens. The AEI score of the entire cohort was 4.2±1.2 (median 4.0) and was higher in Athens compared to Thessaloniki (4.3±1.2 vs. 4.0±1.2, p=0.001) and in girls than boys (4.3±1.1 vs. 4.0±1.2, p=0.001). AEI was inversely associated with lifetime asthma (OR: 0.87, 95%CI 0.77, 0.99) in either cities independently of other cofounders such as family history, sensitisation, exercise, house smoking, breast feeding, pet or dampness in houses. No association with other allergic disease or sensitisation was detected.


Antioxidant foods seem to be a non-pharmacological, protective dietary pattern for asthma development in children irrespectively of atopy or heredity; AEI was a rough indicator and the role of antioxidants in allergic diseases is still under consideration.



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