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Vol. 45. Issue 3.
Pages 297-304 (May - June 2017)
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Vol. 45. Issue 3.
Pages 297-304 (May - June 2017)
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DOI: 10.1016/j.aller.2016.08.002
Allergenicity of vertebrate tropomyosins: Challenging an immunological dogma
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J. González-Fernándeza,
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quintas_copo@hotmail.com

Corresponding author.
, A. Daschnerb, C. Cuéllara
a Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
b Servicio de Alergia, Instituto de Investigación Sanitaria-Hospital Universitario de La Princesa, 28006 Madrid, Spain
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Table 1. Known and hypothetical factors affecting allergenicity of tropomyosins from different sources.
Abstract

With the exception of tilapia tropomyosin, other anecdotic reports of tropomyosin recognition of vertebrate origin are generally not accompanied by clinical significance and a dogmatic idea is generally accepted about the inexistence of allergenicity of vertebrate tropomyosins, based mainly on sequence similarity evaluations with human tropomyosins. Recently, a specific work-up of a tropomyosin sensitised patient with seafood allergy, demonstrated that the IgE-recognition of tropomyosin from different fish species can be clinically relevant. We hypothesise that some vertebrate tropomyosins could be relevant allergens. The hypothesis is based on the molecular evolution of the proteins and it was tested by in silico methods. Fish, which are primitive vertebrates, could have tropomyosins similar to those of invertebrates. If the hypothesis is confirmed, tropomyosin should be included in different allergy diagnosis tools to improve the medical protocols and management of patients with digestive or cutaneous symptoms after fish intake.

Keywords:
Cross-reactivity
Evolution
Fish
IgE
Panallergen
Tropomyosin

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