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Inicio Allergologia et Immunopathologia Adverse reactions and influencing factors in children with primary immunodeficie...
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Original Article
DOI: 10.1016/j.aller.2020.05.008
Available online 22 July 2020
Adverse reactions and influencing factors in children with primary immunodeficiencies receiving intravenous immunglobulin replacement
I.B.P. Ibisa,
Corresponding author

Corresponding author.
, B. Erdura, S.B. Erdemb, S. Karamanb, N. Gulezb, F. Genelb
a Department of Pediatrics, Dr. Behcet Uz Children’s Hospital, Izmir, Turkey
b Department of Pediatric Immunology, Dr. Behcet Uz Children’s Hospital, Izmir, Turkey
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Tables (5)
Table 1. Sociodemographic properties of the patients.
Table 2. Immediate and delayed adverse effects in total of the infusions.
Table 3. Adverse effects according to the diagnosis of the patients.
Table 4. Distribution of adverse effects in terms of total infusions.
Table 5. Logistic regression analysis of the risk factors for adverse reaction development related to IVIG.
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We aimed to determine adverse reactions and influencing factors, within the scope of the number of patients and total infusions, in patients with primary immunodeficiencies receiving intravenous immunoglobulin (IVIG) replacement.

Materials and methods

Children with primary immunodeficiencies receiving IVIG replacement in Izmir Dr Behcet Uz Children’s Hospital, between June 2014 and June 2016, were included in our study.


The total number of the patients receiving IVIG replacement was 145 (37 female, 108 male). The number of total IVIG infusions was 1214. Adverse reactions were observed in 44.8% of the patients and 14.2% of the infusions. Common variable immunodeficiency was the most common diagnosis of the patients and adverse reactions most commonly developed in this group (24.2%). In all infusions the most frequent adverse reaction was headache (7.8%); fever was the most frequent immediate side effect (3.9%), whereas headache was the most common delayed adverse effect (5.1%). By logistic regression analyses, history of adverse reaction to IVIG in previous infusions, existence of concomitant infectious disease, past or family history of atopic disease, to receive IVIG infusion at the first time, or being under 10 years old were found associated with adverse reactions. There was no correlation between the concentration of IVIG preparations and the rate of side-effect development.


In our study no severe adverse reaction to IVIG was observed, but many mild or moderate side effects occurred. Therefore, IVIG indications must be well identified. Patients, family of the patients and health care workers must be informed for adverse reactions.

Primary immunodeficiency
Adverse reactions


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