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Vol. 47. Issue 3.
Pages 209-213 (May - June 2019)
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Vol. 47. Issue 3.
Pages 209-213 (May - June 2019)
Original Article
DOI: 10.1016/j.aller.2018.04.007
Adherence to the Mediterranean diet and inflammatory markers in children with asthma
Konstantinos Dourosa,
Corresponding author

Corresponding author.
, Maria-Ioanna Thanopouloua, Barbara Boutopouloua, Anna Papadopouloub, Anastassios Papadimitrioub, Andrew Fretzayasb, Kostas N. Priftisa
a Children's Respiratory and Allergy Clinic, 3rd Dept of Paediatrics, National and Kapodistrian University of Athens, “Attikon” General University Hospital, Athens, Greece
b 3rd Dept of Paediatrics, National and Kapodistrian University of Athens, “Attikon” University Hospital, Athens, Greece
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Table 1. Clinical characteristics of patients and controls.

There is accumulated evidence supporting a beneficial role of Mediterranean diet (MD) in the control of asthma symptoms. The aim of this study was to investigate the relationships between adherence to MD and serum levels of certain cytokines namely, interleukin (IL)-4, and IL-17 known to have a pathogenetic role in the airway changes associated with asthma.


We measured serum IL-4, IL-33, and IL-17, in 44 asthmatic and 26 healthy children, 5–15 years old. Their adherence to MD was estimated with the Mediterranean Diet Quality Index for children and adolescents (KIDMED) score.


KIDMED score did not differ between the two groups (P=0.59) and was not correlated with any of the three measured cytokines. However, when the analysis was restricted only to asthmatic children, the KIDMED score was correlated with IL-4, IL-33, and IL-17 (Beta: −0.56, P=0.007; Beta: 0.57, P=0.010; Beta: −0.62, P=0.017, respectively).


Our results indicate that MD can modulate the production of some of the main inflammatory mediators of asthma, in asthmatic children.

Mediterranean diet


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