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Inicio Allergologia et Immunopathologia A review on emerging frontiers of house dust mite and cockroach allergy research
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Vol. 44. Issue 6.
Pages 580-593 (November - December 2016)
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Vol. 44. Issue 6.
Pages 580-593 (November - December 2016)
Review
DOI: 10.1016/j.aller.2015.11.001
A review on emerging frontiers of house dust mite and cockroach allergy research
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S. Patela,
Corresponding author
seemabiotech83@gmail.com

Corresponding author.
, B.R. Meherb
a Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego 92182, USA
b Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India
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Table 1. Mites and cockroach species causing allergies, their allergens and biochemical properties.
Abstract

Currently, mankind is afflicted with diversified health issues, allergies being a common, yet little understood malady. Allergies, the outcome of a baffled immune system encompasses myriad allergens and causes an array of health consequences, ranging from transient to recurrent and mild to fatal. Indoor allergy is a serious hypersensitivity in genetically-predisposed people, triggered by ingestion, inhalation or mere contact of allergens, of which mite and cockroaches are one of the most-represented constituents. Arduous to eliminate, these aeroallergens pose constant health challenges, mostly manifested as respiratory and dermatological inflammations, leading to further aggravations if unrestrained. Recent times have seen an unprecedented endeavour to understand the conformation of these allergens, their immune manipulative ploys and other underlying causes of pathogenesis, most importantly therapies. Yet a large section of vulnerable people is ignorant of these innocuous-looking immune irritants, prevailing around them, and continues to suffer. This review aims to expedite this field by a concise, informative account of seminal findings in the past few years, with particular emphasis on leading frontiers like genome-wide association studies (GWAS), epitope mapping, metabolomics etc. Drawbacks linked to current approaches and solutions to overcome them have been proposed.

Keywords:
Allergy
Mite
Cockroach
Hypersensitivity
Serine protease
Epitope mapping
Genome wide association studies
Metabolomics

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