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Vol. 36. Issue 5.
Pages 306-311 (May 2012)
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Vol. 36. Issue 5.
Pages 306-311 (May 2012)
Original article
DOI: 10.1016/j.acuroe.2012.08.013
RNASEL study of genetics of prostate cancer and its relation to clinical staging
Estudio genético de RNASEL en cáncer de próstata y su relación con la estadificación clínica
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M.J. Álvarez-Cuberoa,??
Corresponding author
mjesusac@ugr.es

Corresponding author.
, M. Saiza, L.J. Martínez-Gonzálezb, J.C. Álvareza,b, J.A. Lorentea,b, J.M. Cozarc
a Laboratorio de Identificación Genética, Departamento de Medicina Legal y Toxicología, Facultad de Medicina, Universidad de Granada, Granada, Spain
b Centro Pfizer, Universidad de Granada, Junta de Andalucía de Investigación Genómica y Oncológica, GENYO, Granada, Spain
c Servicio de Urología, Hospital Universitario Virgen de las Nieves, Granada, Spain
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Tables (3)
Table 1. Clinical information of patients and controls of this study.
Table 2. Primers sequence HPC1 gene (RNASEL).
Table 3. Results of the genotypes studied and stage of cancer.
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Abstract
Objectives

This study has aimed to find a possible genetic relationship between sporadic prostate cancers. An attempt is made to establish population subgroups in patients based on the genotype found and the aggressiveness of the cancer.

Materials and methods

A total of 231 patients with sporadic prostate cancer and 68 controls were selected. The subjects were selected by an urologist using clinical parameters such as Prostate Specific Antigen (PSA) level and Gleason score. Both groups (patients and controls) were genotyped in RNASEL gene by sequencing the exons 1 and 3.

Results

Statistically significant differences were found between controls and patients in some of the genotyped regions of the RNASEL gene (I97L, D541E and R462Q).

Conclusions

Thanks to the genetic profile in some regions of the genoma, such as the RNASEL gene, together with the combination of the clinical and environmental parameters, we can suggest a care and more personalized follow-up of each patient.

Keywords:
Prostate cancer
Genetic
RNASEL
Resumen
Objetivos

Mediante este estudio se pretende buscar una posible relación genética en el cáncer de próstata esporádico, para intentar establecer subgrupos poblacionales en los pacientes en función del genotipo encontrado y la agresividad del cáncer.

Material y métodos

231 pacientes con cáncer prostático esporádico y 68 individuos control, todos seleccionados según criterios de parámetros clínicos (grado de PSA, escala de Gleason...) por el urólogo especialista. Ambos grupos (pacientes y controles) han sido genotipados mediante técnicas de secuenciación tanto en los exones 1 y 3 del gen RNASEL.

Resultados

Se han encontrado diferencias significativas entre controles y pacientes en algunas de las regiones genotipadas del gen RNASEL(I97L,D541E y R462Q).

Conclusiones

Gracias a la caracterización del perfil genético en determinadas regiones del genoma, como el gen RNASEL, junto con la combinación de los parámetros clínicos y ambientales; podemos generar una medicina y seguimiento más personalizado de cada individuo.

Palabras clave:
Cáncer de próstata
Genética
RNASEL

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