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Vol. 46. Issue 5.
Pages 317-322 (June 2022)
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Vol. 46. Issue 5.
Pages 317-322 (June 2022)
Original article
Metabolic syndrome in calcium oxalate stones: Is it so important in this type of lithiasis?
Síndrome metabólico en los cálculos de oxalato cálcico: ¿es tan importante en este tipo de litiasis?
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I. Laso Garcíaa,
Corresponding author
ines.laso.garcia@gmail.com

Corresponding author.
, V. Gomez Dos Santosa, A. Sánchez Herranzb, G. Duque Ruiza, F. Arias Fúneza, M. Hevia Palaciosa, F.J. Burgos Revillaa
a Departamento de Urología, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, Spain
b Departamento de Bioquímica, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, Spain
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Tables (3)
Table 1. Biochemical and hormone levels.
Table 2. Correlations between various parameters related to metabolic syndrome.
Table 3. Correlations between glucose, cholesterol, and triglycerides, as well as testosterone and estradiol.
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Abstract
Introduction and objective

The association of the metabolic syndrome with lithogenesis has been described, especially in uric acid stones.

The aim of the work was to analyze the role of the metabolic syndrome in oxalocalcic lithogenesis.

Materials and methods

Metabolic evaluation of 151 patients including biochemical, hormonal and 24-urine urine parameters, as well as characteristics associated with metabolic syndrome.

The relationship between the characteristics associated with the metabolic syndrome and those related to lithogenesis was evaluated using Spearman's correlation coefficient (SCC), Student's t test and Fisher's exact test.

Results

The average body mass index (BMI) was 25.9 (SD 3.7). The median age was 51 years (18.6–84.8) and 64.9% were men.

There were no statistically significant differences between hypertension and estradiol, testosterone, triglycerides or cholesterol (P=.191, .969, .454, .345, respectively). Regarding glucose, the mean was 114.5 and 93.5mg/dl in patients with and without hypertension (P=.000). The levels of glucose, estradiol, testosterone or cholesterol did not vary with proteinuria (P=.518, P=.227, P=.095, P=.218, respectively). The mean triglycerides were 185.6 and 108.2mg/dl in patients with and without proteinuria (P=.001). Hypertension and proteinuria were not associated (P=.586). BMI correlated with serum and urinary uric acid and urinary creatinine.

Conclusions

There are few associations between the characteristics of the metabolic syndrome and the anomalies related to lithogenesis. Metabolic syndrome does not seem to have a relevant role in the development of oxalocalcic stones.

Keywords:
Oxalocalcic
Lithiasis
Metabolic syndrome
Obesity
Diabetes
Hypertension
Resumen
Introducción y objetivo

Se ha descrito la asociación del síndrome metabólico con la litogénesis, especialmente en cálculos de ácido úrico.

El objetivo de este trabajo es analizar la importancia del síndrome metabólico en la litogénesis oxalocálcica.

Materiales y métodos

Evaluación metabólica de 151 pacientes: parámetros bioquímicos, hormonales y orina de 24 horas; características asociadas al síndrome metabólico.

Se evaluó la relación entre las características asociadas con el síndrome metabólico y las relacionadas con la litogénesis mediante el coeficiente de correlación de Spearman (CCS), t de Student y prueba exacta de Fisher.

Resultados

El índice de masa corporal promedio (IMC) fue 25,9 (DE 3,7). La mediana de edad fue 51 años (18,6–84,8) y 64,9% eran hombres.

No hubo diferencias estadísticamente significativas entre hipertensión y estradiol, testosterona, triglicéridos o colesterol (P>.05). Referente a la glucosa, la media fue 114.5 y 93.5mg/dl en pacientes con y sin hipertensión (P=,000). Los niveles de glucosa, estradiol, testosterona o colesterol no variaron con la proteinuria (P>.05). La media de triglicéridos fue 185.6 y 108.2mg/dl en pacientes con y sin proteinuria (P=,001). La hipertensión y la proteinuria no se asociaron (P=,586). El IMC se correlacionó con el acido úrico sérico y urinario y la creatinina urinaria.

Conclusiones

Existen pocas asociaciones entre las características del síndrome metabólico y las anomalías relacionadas con la litogénesis. El síndrome metabólico no parece tener un papel relevante en el desarrollo de cálculos oxalocálcicos.

Palabras clave:
Oxalocálcico
Litiasis
Síndrome metabólico
Obesidad
Diabetes
Hipertensión

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