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Vol. 39. Issue 4.
Pages 245-252 (May 2015)
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Vol. 39. Issue 4.
Pages 245-252 (May 2015)
Review article
Implications of vitamin D deficiency in lithiasic patient and in general population
Implicaciones del déficit de vitamina D en el paciente litiásico y en la población general
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140
F. Millán-Rodrígueza,
Corresponding author
, P. Gavrilova, S. Gracia-Garcíab, O. Angerri-Feua, F.M. Sánchez-Martína, H. Villavicencio-Mavricha
a Servicio de Urología, Fundació Puigvert, Barcelona, Spain
b Servicio de Bioquímica, Fundació Puigvert, Barcelona, Spain
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Tables (3)
Table 1. Biochemical findings.
Table 2. Levels of 25OH-vitamin D.
Table 3. Linear regression model predictive of PTH values.
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Abstract
Context and objective

Vitamin D deficiency causes problems in mineral metabolism but also overall health. In first place a review of the topic was carried out. Then, in order to contextualize it in lithiasic patient, a study on Vitamin D deficiency and its possible relationship with impaired PTH levels is performed.

Evidences acquisition

A review of topics such as metabolism, epidemiology and the relationship of vitamin D deficiency with several pathologies was performed. Besides a multivariate analysis and a correlation study between vitamin D and PTH levels were conducted in 100 lithiasic patients.

Evidences synthesis

We present a review of Vitamin D metabolism, receptors and functions, as well as about its valuation methodology and the treatment of its deficiency. Lithiasic patients show a higher vitamin D deficiency than general population. Vitamin D deficiency has been significantly associated with increased PTH levels. In addition, there is enough literature showing a relationship between vitamin D deficiency not only with bone disease, but also with multiple diseases.

Conclusion

vitamin D levels should be measured in all lithiasic patients, and those with vitamin D deficiency should be treated.

Keywords:
Vitamin D
Parathyroid hormone
Urinary lithiasis
Phosphocalcic metabolism
Resumen
Contexto y objetivo

El déficit de vitamina D ocasiona problemas en el metabolismo fosfocálcico, pero también de salud general. El objetivo es realizar una revisión del tema, y para contextualizarlo en el paciente litiásico realizar un estudio sobre el déficit de vitamina D y su posible relación con la alteración de los valores de PTH.

Adquisición de evidencias

Revisión del metabolismo, la epidemiología y la relación del déficit de vitamina D con varias enfermedades. Análisis multivariable y estudio de correlación entre los niveles de vitamina D y PTH en 100 pacientes litiásicos.

Síntesis de evidencias

Se presenta una revisión sobre el metabolismo, receptores, funciones y valoración de la vitamina D, así como del tratamiento de su déficit. Se ha encontrado un déficit de vitamina D superior en el paciente litiásico que en la población general y que se relaciona significativamente con un incremento de los valores de PTH. Además hay suficiente literatura que muestra una relación del déficit de vitamina D no solo con enfermedad ósea, sino con múltiples enfermedades.

Conclusión

En todo paciente litiásico debe descartarse y tratarse un posible déficit de vitamina D.

Palabras clave:
Vitamina D
Hormona paratiroidea
Litiasis urinaria
Metabolismo fosfocálcico

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