Buscar en
Actas Urológicas Españolas (English Edition)
Toda la web
Inicio Actas Urológicas Españolas (English Edition) Association of nocturnal penile rigidity with testosterone, metabolic syndrome, ...
Journal Information
Vol. 35. Issue 8.
Pages 459-467 (September 2011)
Share
Share
Download PDF
More article options
ePub
Visits
1273
Vol. 35. Issue 8.
Pages 459-467 (September 2011)
Original article
DOI: 10.1016/j.acuroe.2011.03.012
Association of nocturnal penile rigidity with testosterone, metabolic syndrome, and other variables: A prospective cross-sectional pilot study
Asociación de la rigidez peneana nocturna con testosterona, síndrome metabólico y otras variables: un estudio piloto prospectivo transversal
Visits
...
O. Rajmila,??
Corresponding author
orajmil@fundacio-puigvert.es

Corresponding author.
, M. Fernándeza, A. Blascob, J.A. Arrúsa, R. Montañésc, J. Rodríguez-Espinosad
a Servicio de Andrología, Fundació Puigvert, Universitat Autònoma de Barcelona, Barcelona, Spain
b Servei Estadistica, Universitat Autonoma de Barcelona, Barcelona, Spain
c Departamento de Laboratorios Clínicos, Fundació Puigvert, Barcelona, Spain
d Departamento de Bioquímica Clínica, Hospital Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Tables (5)
Table 1. Characteristics of the 234 men consulting for ED: comparison of variables used for diagnosis of MetS (NCEP-ATPIII criteria: diagnosis required the presence of at least three of the variables) among groups with and without normal nocturnal erections and MetS.
Table 2. Characteristics of the 234 men consulting for ED: comparison of further variables (not used in the diagnosis of MetS according to NCEP-ATPIII) and testosterone among groups with and without normal nocturnal erections and MetS criteria.
Table 3. Results of univariate logistic regression models (unadjusted and adjusted for age and MetS) for the association of total and bioavailable testosterone with prevalence of ED.
Table 4. Results of univariate logistic regression models (unadjusted and adjusted for age) for the association of total and bioavailable testosterone with the prevalence of ED in groups with and without MetS.
Table 5. Relative risk of prevalence of ED: results of multivariate logistic regression models for the association of biochemical markers grouped according to the presence (model 1) or absence (model 2) of MetS.
Show moreShow less
Abstract
Introduction

The aim was to study whether nocturnal penile rigidity (NPTR) correlates with metabolic syndrome (MetS) and testosterone in men consulting for erectile dysfunction (ED).

Materials and methods

234 men were included in a prospective, cross-sectional pilot study. Serum total and bioavailable testosterone and other biochemical constituents were measured and compared with NPTR. Patients were classified by normal or low/abnormal penile rigidity (abnormal meaning predominant organic component of ED) and presence or absence of MetS to test the hypothesized correlations.

Results

Application of the logistic regression model to rigidity as the dependent variable showed the risk of low penile rigidity to be significantly lower for patients with higher total (OR=0.96, 95% CI=0.92, 0.99) or bioavailable testosterone (OR=0.91, 95% CI=0.84, 0.99). Patients with testosterone levels between 8 and 12mmol/L had a quadrupled risk of low penile rigidity compared with patients with higher levels (>12mmol/L) (OR=3.96, 95% CI=1.89, 8.31). Considering men without MetS, age and body mass index were associated as significant factors for low penile rigidity: age increased risk by 8% (OR=1.08, 95% CI=1.03, 1.13) and BMI increased it by 18% (OR=1.18, 95% CI=1.01, 1.38).

Conclusion

Testosterone levels are weakly associated with penile rigidity and disappear when associated with MetS.

Keywords:
Erectile dysfunction
Penile rigidity
Testosterone
Metabolic syndrome
Body mass index
Resumen
Introducción

El objetivo fue estudiar la relación entre la rigidez de las erecciones nocturnas (NPTR) con el síndrome metabólico (SM) y la testosterona en varones que consultan por trastornos de erección (DE).

Material y método

Se incluyeron 234 varones en un estudio piloto prospectivo y transversal. Se midieron los niveles séricos de testosterona total y biodisponible y otros parámetros bioquímicos relacionados con el SM y con las NPTR. Los pacientes se agruparon según la rigidez de las erecciones: normales (alta rigidez, componente predominante psicológico de la disfunción) o anormales (baja rigidez, posible componente orgánico o físico de la DE) y por la presencia o ausencia de SM.

Resultados

El modelo de regresión logística para la rigidez del pene como variable dependiente demostró que el riesgo de rigidez anormal es menor en individuos con mayor testosterona total (OR=0,96; 95% CI=0,92, 0,99) o biodisponible (OR=0,91; 95% CI=0,84, 0,99). Pacientes con niveles de testosterona entre 8 y 12mmol/L presentaron un riesgo cuatro veces mayor de tener rigidez anormal comparados con aquellos con niveles superiores a 12mmol/L (OR=3,96; 95% CI=1,89, 8,31). Si se consideraban únicamente aquellos varones sin MetS, solo la edad y el índice de masa corporal aparecían como factores de riesgo asociados a la rigidez anormal. La edad aumentó el riesgo de rigidez anormal en un 8% (OR=1,08; 95% CI=1,03, 1,13) y el MI lo aumentó en un 18% (OR=1,18; 95% CI=1,01, 1,38).

Conclusión

La asociación de niveles de testosterona con la rigidez del pene fue baja y desaparece si se asocia con SM.

Palabras clave:
Disfunción eréctil
Rigidez peneana
Testosterona
Hipogonadismo
Síndrome metabólico
Índice de masa corporal

Article

These are the options to access the full texts of the publication Actas Urológicas Españolas (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Actas Urológicas Españolas (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos