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Rábago, J. Rioja Zuazu, F.I. Rodríguez-Rubio Cortadellas, J.J. Zudaire Bergera, A. Saiz Sansi, D. Rosell Costa, J.E. Robles García, J.M. Berián Polo" "autores" => array:8 [ 0 => array:2 [ "nombre" => "G." "apellidos" => "Rábago" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Rioja Zuazu" ] 2 => array:2 [ "nombre" => "F.I." "apellidos" => "Rodríguez-Rubio Cortadellas" ] 3 => array:2 [ "nombre" => "J.J." "apellidos" => "Zudaire Bergera" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Saiz Sansi" ] 5 => array:2 [ "nombre" => "D." "apellidos" => "Rosell Costa" ] 6 => array:2 [ "nombre" => "J.E." "apellidos" => "Robles García" ] 7 => array:2 [ "nombre" => "J.M." "apellidos" => "Berián Polo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608738531?idApp=UINPBA00004N" "url" => "/02104806/0000003200000004/v1_201304251904/S0210480608738531/v1_201304251904/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Recidiva bioquímica precoz tras prostatectomía radical retropúbica por cáncer de próstata. Factores implicados. ¿Influye el tiempo de espera entre biopsia y cirugía?" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "406" "paginaFinal" => "410" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Blanco Díez, J. Armas Molina, J.Mª. Limiñana Canal, C. Jiménez García, J.L. Artíles Hernández, N. Chesa Ponce" "autores" => array:6 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Blanco Díez" "email" => array:1 [ 0 => "abdiez2003@yahoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Armas Molina" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J.Mª." "apellidos" => "Limiñana Canal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "C." "apellidos" => "Jiménez García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "J.L." "apellidos" => "Artíles Hernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "N." "apellidos" => "Chesa Ponce" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Investigación. Hospital Universitario Insular de Gran Canaria. Las Palmas de Gran Canaria" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Urología. Unidad de Investigación. Hospital Universitario Insular de Gran Canaria. Las Palmas de Gran Canaria" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. J. Rioja Zuazu Dept. Urology G4. Academisch Medisch Centrum Meibergdreef 9 - 1105 AZ Amsterdam The Netherlands Holanda Tel.: +31 205 669 111" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Early biochemical failure after radical prostatectomy for prostate cancer. impact factors? Does delay from biopsy to surgery have any influence?" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-10-01" "fechaAceptado" => "2007-11-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88552" "palabras" => array:3 [ 0 => "Cáncer de próstata" 1 => "Recurrencia" 2 => "Biopsia de próstata" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec88551" "palabras" => array:3 [ 0 => "Prostate cancer" 1 => "Recurrence" 2 => "Prostate biopsy" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Resumen</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Recidiva bioquímica precoz tras prostatectomía radical retropúbica por cáncer de próstata. factores implicados. ¿influye el tiempo de espera entre biopsia y cirugía?</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudiar diferentes factores que pueden influir en la recidiva bioquímica precoz (RBP) (primer año tras cirugía), tras prostatectomía radical retropúbica (PRR)</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudiamos 310 PRR. Criterios de inclusión: al menos un año de seguimiento, ausencia de bloqueo hormonal o radioterapia previa. Los pacientes fueron divididos inicialmente en 2 grupos según el tiempo de espera. Grupo A <90 días (n: 148), Grupo B>90 días (n:162). Estudiamos RBP (2 o más determinaciones de PSA>= 0,2 ng/ml) y la influencia del PSA previo, el Gleason de la biopsia, el Gleason del espécimen, estadio pT, y tiempo de espera. Para estudiar la homogeneidad existente entre los dos grupos usamos la t de Student o W de Wilcoxon. Estudiamos la RBP y el estadio pT en los dos grupos usando la chi cuadrado de Pearson, que también nos sirve para estudiar en los dos grupos la RBP en relación al estadio pT. El test de la U de mann-Whitney lo usamos para estudiar en la serie global la RBP según el Gleason del espécimen. Por último se realiza una Regresión logística multivariante para estudiar la influencia de todas las variables en la RBP en la serie global</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">No encontramos diferencias entre los dos grupos en edad (p< 0,129), ni PSA (p< 0,479), ni Gleason de biopsia (p<0,913). No se encontraron diferencias en RBP ni en estadio pT según el tiempo de espera. Hallamos diferencias estadísticamente significativas en RBP si estudiamos estadio pT y Gleason de la pieza. Los T3 tienen más incidencia de recurrencia que los T2 y hay más incidencia de RBP según aumenta el Gleason de la pieza. En la regresión logística de la serie global las variables independientes de progresión son: PSA previo y estadio pT. Ni el Gleason de la biopsia ni el Gleason del espécimen, ni el tiempo de espera entre biopsia y cirugía influyen en la RBP</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El Gleason de la biopsia y el tiempo de espera no influyen en la RBP. El tiempo de espera tampoco influye en el estadio T final. En nuestra serie las diferencias en RBP vienen dadas por el PSA previo y pT. El Gleason del espécimen parece influir en la RBP, pero en menor proporción sin significado en el análisis multivariante</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Early biochemical failure after radical prostatectomy for prostate cancer. impact factors? Does delay from biopsy to surgery have any influence?</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To determine wether WT may impact on the EBF (before one year) alter RRP in our series, and to study other factors that may impact on this issue</p> <span class="elsevierStyleSectionTitle">Material and Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We study 310 RRP. Inclusion criteria are: one year follow up, no hormonal manipulation neither previous radiotherapy. Patients are divide in two groups attending WT. Group A < 90 days (n: 148), Group B>90 days (n: 162). We study EBF (2 or more PSA determinations>= 0.2 ng/ml), and the impact of previous PSA, biopsy Gleason, Gleason of the specimen (G), pT stage (pT), and WT. T of Student or W of Wilcoxon are used to determine the homogeneity of the two groups. Chi Square of Pearson to compare the two group’s EBF and pT attending to WT and EBF attending to pT. U of Mann Whitney is used to study EBF attending to G. Multivariate logistic regresion (LR) is used to study the impact of the variables on EBF</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">There are no differences between the two groups in age (p< 0.129), PSA (p< 0.479), biopsy´s Gleason (p<0.913). There are no differences in EBF nor in pT attending to WT. Significant statystical differences are founded in EBF attending to pT and G. T3 tumors have more chance of recurrence than T2. EBF is more frecuent as G increases. In logistic regresion of the global serie, independent variables for progression are: Previous PSA and pT. Nor biopsy´s Gleason nor specimen´s Gleason, nor WT, impact on the EBF</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Biopsy Gleason and WT do not impact on EBF. WT do not impact on pT. In our serie differences on EBF are lead by previous PSA and pT. Also Gleason of the especimen seems to impact on EBF, but in lower proportion, with no significance in multivariate analysis</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guideline for the management of clinically localized prostate cancer: 2007 update" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Thompson" 1 => "J.B. Thrasher" 2 => "G. 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Journal Information
Recidiva bioquímica precoz tras prostatectomía radical retropúbica por cáncer de próstata. Factores implicados. ¿Influye el tiempo de espera entre biopsia y cirugía?
Early biochemical failure after radical prostatectomy for prostate cancer. impact factors? Does delay from biopsy to surgery have any influence?
A. Blanco Díeza,1
, J. Armas Molinaa, J.Mª. Limiñana Canal*, C. Jiménez Garcíaa, J.L. Artíles Hernándeza, N. Chesa Poncea
Corresponding author
abdiez2003@yahoo.es
Correspondencia autor: Dr. J. Rioja Zuazu Dept. Urology G4. Academisch Medisch Centrum Meibergdreef 9 - 1105 AZ Amsterdam The Netherlands Holanda Tel.: +31 205 669 111
Correspondencia autor: Dr. J. Rioja Zuazu Dept. Urology G4. Academisch Medisch Centrum Meibergdreef 9 - 1105 AZ Amsterdam The Netherlands Holanda Tel.: +31 205 669 111