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Inicio Acta Otorrinolaringológica Española Proteína p53 mediante inmunohistoquímica en el carcinoma epidermoide de laring...
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Vol. 54. Issue 4.
Pages 263-268 (April 2003)
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Vol. 54. Issue 4.
Pages 263-268 (April 2003)
Proteína p53 mediante inmunohistoquímica en el carcinoma epidermoide de laringe
A inmunohistochemistry study of p53 protein in squamous cell carcinoma of the larynx
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A. Pérez-carro ríos1, A. Clemente garcía
Hospital xeral-cíes de vigo. pontevedra
A. Lozano ramírez*, T. García caballero*, T. Labella caballero*
* Hospital clínico universitario de santiago de compostela. a coruña
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Resumen

La proteína p53 actúa detectando el adn celular dañado, deteniendo el ciclo celular para repararlo y estimulando la "apoptosis" o muerte celular programada cuando no lo consigue. realizamos un estudio mediante inmunohistoquímica de 58 carcinomas epidermoides de laringe intervenidos de su patología entre 1991 y 1996 siendo la proteína mutada positiva en 31 casos (53,44%). no encontramos una relación estadísticamente significativa mediante el análisis estadístico de log rank entre la supervivencia y la positividad para la proteína p53, siendo la supervivencia media para los casos negativos para la proteína de 64 meses de media, muy similar a los casos que presentan la proteína mutada.

Palabras clave:
P53
Proteína supresora
Carcinoma epidermoide
Laringe
Pronóstico
Summary

p53 protein detects damages in dna, stopping the cellular cycle to repair it and stimulates "apoptosis" or programmed death cell when it cannot do it. we present an inmunohistochemistry study of 58 squamous cell carcinomas of larynx operated between 1991 and 1996 and in wich we detected the overexpression of p53 in 31 cases (53.44%). we did not find a statistic relationship between survival and the detection of p53 protein using log rank statistic analysis; the survival media for the wild-type protein cases was 64 months (very similar to native cases)

Key words:
P53
Suppress protein
Squamous cell carcinoma
Larynx
Survival

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