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Journal Information
Vol. 56. Issue 2.
Pages 68-73 (February 2005)
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Vol. 56. Issue 2.
Pages 68-73 (February 2005)
Hipoacusia asociada a colitis ulcerosa
Hearing loss associated to ulcerative colitis
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F.J. García Callejoa
Corresponding author
jgarciacall@hotmail.com

Francisco Javier García Callejo C/ Luis Oliag 71 – 8 46006 Valencia
, M.H. Orts Alborch, C. de Paula Vernetta, J. Marco Algarra
Servicio de Otorrinolaringología
P. Laporta Marín*, M.M. Velert Vila**
* Departamento de Bioquímica. Hospital Clínico Universitario de Valencia
** Centro de Investigación. Hospital La Fe. Valencia
Article information
Resumen
Objetivos

Evaluar la eventual inmunomediación en hipoacusias neurosensoriales (HNS) en pacientes con colitis ulcerosa (CU)

Material y métodos

En 49 casos, con edad media de 41,6±9,3 años, se estudiaron grado de hipoacusia, indicadores de actividad de enfermedad, marcadores de inflamación en sangre periférica y anticuerpos anticocleares mediante western-blot (WB)

Resultados

El 26,5% documentaban sordera conocida, aunque se detectó HNS en el 59,1% de los casos. Su edad media de aparición fue de 40,3±9,8 años. En el 48,9% se identificó un WB positivo, detectándose siempre la banda de 68-70 kD. Los pacientes con WB positivo mostraron mayor grado de hipoacusia, actividad de enfermedad y más parámetros sanguíneos alterados, en especial la velocidad de sedimentación globular

Conclusiones

Los hallazgos audiológicos y en sangre periférica observados permiten establecer la sospecha razonable de que la hipoacusia detectada en la CU presenta un mecanismo de producción autoinmune o inmunomediado

Palabras clave:
Hipoacusia
Colitis ulcerosa
Western-blot
Abstract
Objetive

To value the eventual immunomediation in sensorineural hearing loss (SHL) on patients bearing of ulcerative colitis (UC)

Material and methods

In a group of forty-nine cases with a mean age of 41,6±9,3 years old we studied the hearing loss level, the disease activity index, the peripheral blood inflammation markers and the anticochlear antibodies by mean of western-blot technique (WB)

Results

The 26,5% knew about their deafness, although SHL was detected in 59,1% of cases. The mean age of onset was 40,3±9,8 years. 48,9% showed a positive WB, always in 68-70 kDa molecular weight blots. Moreover, patients with positive WB showed more severe deafness, higher disease activity and more altered parameters, specially erythrosedimenta erythrosedimentation rate

Conclusions

Audiologic and peripheral blood findings observed allow us to establish a reasonable suspicion of an autoimmune or immunomediated pathway of hearing loss on UC

Key words:
Deafness
Ulcerative colitis
Western-blot

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