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Vol. 54. Issue 7.
Pages 506-511 (September 2003)
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Vol. 54. Issue 7.
Pages 506-511 (September 2003)
Detección del virus herpes simplex y del virus de epstein-barr en los carcinomas de células escamosas de vías aerodigestivas superiores
Detection of herpes simplex virus and epstein-barr virus in head and neck squamous cell carcinoma
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A. López llames
,1
Corresponding author
aurora@seorl.net

Correspondencia: C/Avenida del Cristo de las Cadenas, nº 53, 1º F. 33006 Oviedo.
, J.L. Llorente pendás*, S. Melón**, J.M. García pedrero***, D. García carracedo***, C. Suárez nieto*
* Servicio de orl, hospital central de asturias
** Servicio de microbiología, hospital central de asturias
*** Instituto universitario de oncología del principado de asturias
Article information
Resumen
Objetivo

Diversos estudios han investigado el papel de los virus en la carcinogénesis de los tumores de cabeza y cuello. A pesar de esto, el mecanismo de la carcinogénesis viral permanece poco claro. El objetivo de este estudio es determinar la prevalencia del virus herpes simplex (VHS) y del virus de Epstein-Barr (VE-B) en tumores malignos de laringe y orofaringe.

Material y método

Se estudian muestras frescas congeladas de 28 pacientes con tumores de laringe y orofaringe. La presencia o ausencia del VHS y VE-B se determinó mediante la reacción en cadena de la polimerasa (PCR).

Resultados

En ninguna de las muestras detectamos el ADN del VE-B. En una muestra de carcinoma de amígdala (3,5%) detectamos el ADN del VHS.

Conclusiones

Nuestros resultados no sugieren que el VHS y el VE-B tengan un papel en la etiología de los tumores de cabeza y cuello.

Palabras clave:
Virus
Carcinoma epidermoide de cabeza y cuello
Abstract
Objective

Previous studies have investigated the role of viruses in tumor origin of head and neck cancer. Despite this, mechanis of viral carcinogenesis remain unclear. The aim of this study is to determine the prevalence of herpes simplex virus (HSV) and Epstein-Barr virus (EBV) in malignant laryngeal and oropharyngeal lesions.

Material and methods

Fresh frozen specimens of 28 laryngeal and oropharyngeal squamous cell carcinomas were studied. The presence or absence of HSV and EBV was determined with polymerase chain reaction (PCR) assays.

Results

None of the samples showed evidence for EBV DNA. One tonsilar carcinoma case (3.5%) was positive for HSV DNA detection.

Conclusions

These results do not support HSV and EBV as etiological factors in head and neck cancer.

Key words:
Viruses
Squamous cell head
neck cancer

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