TY - JOUR T1 - A case-control study on the clinical impact of ventilator associated tracheobronchitis in adult patients who did not develop ventilator associated pneumonia JO - Enfermedades Infecciosas y Microbiología Clínica (English Edition) T2 - AU - Cantón-Bulnes,María Luisa AU - González-García,María Ascensión AU - García-Sánchez,Manuela AU - Arenzana-Seisdedos,Ángel AU - Garnacho-Montero,José SN - 2529993X M3 - 10.1016/j.eimce.2017.12.004 DO - 10.1016/j.eimce.2017.12.004 UR - https://www.elsevier.es/en-revista-enfermedades-infecciosas-microbiologia-clinica-english-428-articulo-a-case-control-study-on-clinical-S2529993X18302545 AB - ObjectivesThe main objective was to determine whether ventilator-associated tracheobronchitis (VAT) is related to increased length of ICU stay. Secondary endpoints included prolongation of hospital stay, as well as, ICU and hospital mortality. DesignA retrospective matched case-control study. Each case was matched with a control for duration of ventilation (±2 days until development of ventilator-associated tracheobronchitis), disease severity (Acute Physiology and Chronic Health Evaluation II) at admission ±3, diagnostic category and age ±10 years. PatientsCritically ill adults admitted to a polyvalent 30-beds ICU with the diagnosis of VAT in the period 2013–2016. Main resultsWe identified 76 cases of VAT admitted to our ICU during the study period. No adequate controls were found for 3 patients with VAT. There were no significant differences in demographic characteristics, reasons for admission and comorbidities. Patients with VAT had a longer ICU length of stay, median 22 days (14–35), compared to controls, median 15 days (8–27), p=0.02. Ventilator days were also significantly increased in VAT patients, median 18 (9–28) versus 9 days (5–16), p=0.03. There was no significant difference in total hospital length of stay 40 (28–61) vs. 35days (23–54), p=0.32; ICU mortality (20.5 vs. 31.5% p=0.13) and hospital mortality (30.1 vs. 43.8% p=0.09). We performed a subanalysis of patients with microbiologically proven VAT receiving adequate antimicrobial treatment and did not observe significant differences between cases and the corresponding controls. ConclusionsVAT is associated with increased length of intensive care unit stay and longer duration of mechanical ventilation. This effect disappears when patients receive appropriate empirical treatment. ER -