TY - JOUR T1 - High prevalence and incidence of HPV-related anal cancer precursor lesions in HIV-positive women in the late HAART era JO - Enfermedades Infecciosas y Microbiología Clínica (English Edition) T2 - AU - Hidalgo-Tenorio,Carmen AU - de Jesus,Samantha E. AU - Esquivias,Javier AU - Pasquau,Juan SN - 2529993X M3 - 10.1016/j.eimce.2018.07.003 DO - 10.1016/j.eimce.2018.07.003 UR - https://www.elsevier.es/en-revista-enfermedades-infecciosas-microbiologia-clinica-english-428-articulo-high-prevalence-incidence-hpv-related-anal-S2529993X18301655 AB - IntroductionAnal cancer is one of the most common non-AIDS defining malignancies, especially in men who have sex with men and women living with HIV (WLHIV). ObjectivesTo evaluate the prevalence and incidence of precursor lesions (high-grade squamous intraepithelial lesions [HSIL]) and anal cancer in our cohort of women and to compare them to cervical lesions; to calculate the percentage of patients that acquire and clear oncogenic genotypes (HR-HPV) in the anal canal; and to determine predictive factors for anal HPV infection. Patients and methodsProspective-longitudinal study (May 2012–December 2016). At baseline (V1) and follow up visits, anal mucosa samples were taken in liquid medium for cytology and HPV PCR. In cases of abnormal anal cytology and/or positive HR-HPV PCR results, a high resolution anoscopy was performed. Patients were also referred to the gynaecologist. ResultsNinety five women with an average age of 43.7 years were included. At baseline, 11.6% had cervical abnormalities (4.1% CIN1, 2.2% CIN2/3, 1.1% cervical cancer), 64.3% anal abnormalities (50% LSIL/AIN1, 9.5% HSIL/AIN2/3 and 2.4% anal cancer) and 49.4% had HR-HPV genotypes. During 36 months of follow up, the incidence of anal HSIL was 16×1000 person-years; 14.8% acquired HR-HPV genotypes and 51.2% cleared them, p=0.007. No patients presented CIN1/2/3/ or cervical cancer. In the multivariate analysis we found the following predictive factors for HR-HPV infection: smoking (RR: 1.55, 95% CI: 0.99–2.42), number of sexual partners >3 (RR: 1.69; 95% CI: 1.09–2.62), cervical and anal dysplasia (RR: 1.83; 95% CI: 1.26–2.67) and (RR: 1.55; 95% CI: 1.021–2.35), respectively. ConclusionsDespite clearance rates of anal oncogenic genotypes being higher than acquisition rates, prevalence and incidence of HSIL were still high and greater than cervical HSIL. Therefore, screening for these lesions should perhaps be offered to all WLHIV. ER -