TY - JOUR T1 - Statin associated myopathy in clinical practice. Results of DAMA study JO - Clínica e Investigación en Arteriosclerosis (English Edition) T2 - AU - Millán,Jesús AU - Pedro-Botet,Juan AU - Climent,Elisenda AU - Millán,Joaquín AU - Rius,Joan SN - 25299123 M3 - 10.1016/j.artere.2016.07.001 DO - 10.1016/j.artere.2016.07.001 UR - https://www.elsevier.es/en-revista-clinica-e-investigacion-arteriosclerosis-english-415-articulo-statin-associated-myopathy-in-clinical-S2529912316000048 AB - Background and objectiveMuscle symptoms, with or without elevation of creatine kinase are one of the main adverse effects of statin therapy, a fact that sometimes limits their use. The aim of this study was to evaluate the clinical characteristics of patients treated with statins who have complained muscle symptoms and to identify possible predictive factors. Patients and methodsA cross-sectional one-visit, non-interventional, national multicenter study including patients of both sexes over 18 years of age referred for past or present muscle symptoms associated with statin therapy was conducted. 3845 patients were recruited from a one-day record from 2001 physicians. ResultsMyalgia was present in 78.2% of patients included in the study, myositis in 19.3%, and rhabdomyolysis in 2.5%. Patients reported muscle pain in 77.5% of statin-treated individuals, general weakness 42.7%, and cramps 28.1%. Kidney failure, intense physical exercise, alcohol consumption (>30g/d in men and 20g/d in women) and abdominal obesity were the clinical situations associated with statin myopathy. ConclusionsMyalgia followed by myositis are the most frequent statin-related side effects. It should be recommended control environmental factors such as intense exercise and alcohol intake as well as abdominal obesity and renal function of the patient treated with statins. ER -