TY - JOUR T1 - Nasopharyngeal colonisation by Streptococcus pneumoniae in Cuban preschool children: Cross-sectional surveys before/after pneumococcal vaccination JO - Vacunas (English Edition) T2 - AU - Chávez Amaro,D.M. AU - Linares-Pérez,N. AU - Casanova González,M.F. AU - Toledo-Romaní,M.E. AU - Rodríguez Valladares,N.N. AU - Rodríguez Noda,L.M. AU - Mirabal Sosa,M. AU - Rodríguez González,M.C. AU - Toraño Peraza,G. AU - García-Rivera,D. AU - Valdés-Balbín,Y. AU - Vérez-Bencomo,V. SN - 24451460 M3 - 10.1016/j.vacune.2019.04.001 DO - 10.1016/j.vacune.2019.04.001 UR - https://www.elsevier.es/en-revista-vacunas-english-edition--259-articulo-nasopharyngeal-colonisation-by-streptococcus-pneumoniae-S2445146019300172 AB - BackgroundNasopharyngeal colonisation (CNF) is considered a “major point” in the evaluation of pneumococal conjugate vaccines (PCVs). A year after the administration of PCVs in Cienfuegos, Cuba, we described the changes in CNF due to Streptococcus pneumoniae in children between 1 and 5 years included in a clinical trial of the new Cuban vaccine candidate PCV7-TT compared to PCV13. MethodA pre–post vaccination evaluation study was conducted based on two cross-sectional surveys. The first pre vaccination survey (2014–2015) included 1135 children. A subsample (n2=555) of vaccinated children was selected through a simple random sample in 2016. The proportions and percentage differences of global CNF and serotypes and for each age group were estimated and compared before and after vaccination. ResultsThe overall proportion of CNF in preschool children ranged from 34.0% to 26.7%, one year after vaccination (p=.00878). The greatest reduction was observed in the group between 2 and 5 years (from 45.8% to 17.6; [p<.0001]). In the group between 12 and 23 months the overall proportion of CNF (48.1%; [p=.002]) increased to expenses of non-vaccine serotypes. In general, CNF was reduced by more than 50% for the five of the common serotypes contained in PCV7-TT. ConclusionsDespite the limitations of the study due to not having a concurrent control group of unvaccinated, the reduction in CNF by vaccine serotypes suggests that the introduction of the PCV7-TT could significantly impact the burden of CNF in children and consequently reduce the rates of disease associated with pneumococcal infection. Subsequent studies would be necessary to evaluate the phenomenon of serotype replacement and its influence on the reduction of effectiveness over pneumococcal disease. ER -