TY - JOUR T1 - Statins as anti-inflammatory agents: A potential therapeutic role in sight-threatening non-infectious uveitis JO - Porto Biomedical Journal T2 - AU - Gilbert,Rose AU - Al-Janabi,Ahmed AU - Tomkins-Netzer,Oren AU - Lightman,Sue SN - 24448664 M3 - 10.1016/j.pbj.2017.01.006 DO - 10.1016/j.pbj.2017.01.006 UR - https://www.elsevier.es/en-revista-porto-biomedical-journal-445-articulo-statins-as-anti-inflammatory-agents-a-S2444866416300836 AB - In addition to the known lipid-lowering effects, statins are now widely accepted to have anti-inflammatory and immunomodulatory effects. Adjunctive use of statins has proven beneficial in the context of a wide range of inflammatory diseases, including rheumatoid arthritis. Evidence also suggests that statins may also have utility in the management of uveitis, a form of sight threatening inflammation which occurs in the eye. In this article, we outline our rationale behind a clinical trial of simvastatin as a steroid-sparing agent in uveitis, to which patient recruitment started last year. Potential risks associated with the clinical use of statins, including putative effects on the eyes, are discussed. ER -