TY - JOUR T1 - Role of homocysteine and vitamin B in bone metabolism JO - Revista Colombiana de Reumatología (English Edition) T2 - AU - Narváez,Jemina AU - Maldonado,Genessis AU - Intriago,María AU - Cárdenas,Jenny AU - Guerrero,Roberto AU - Luis Neyro,José AU - Ríos,Carlos SN - 24444405 M3 - 10.1016/j.rcreue.2019.12.008 DO - 10.1016/j.rcreue.2019.12.008 UR - https://www.elsevier.es/en-revista-revista-colombiana-reumatologia-english-edition--474-articulo-role-homocysteine-vitamin-b-in-S2444440520300923 AB - Several studies have suggested a role for the vitamin B group in bone physiology. This article discusses a systematic review of the literature on the interaction of vitamin B with homocysteine and their relationship with bone metabolism and osteoporosis. Some studies have suggested that low levels of vitamin-B, particularly B12 and B9, have been associated with a low bone mineral density and an increased risk of fracture, in addition to participating in the metabolism of homocysteine; therefore, the deficit of these vitamins may lead to hyperhomocysteinemia. Recent publications suggest that hyperhomocysteinemia is associated with bone demineralization, low quality of bone mass, and increased levels of bone turnover biomarkers, since it affects the osteoclastic activity and the cross-linking of collagen molecules. Therefore, hyperhomocysteinemia could play a role in reduced bone density and quality. Further information is needed to establish whether each vitamin directly impacts bone health, or if their influence is merely through the homocysteine serum concentrations. ER -