TY - JOUR T1 - Immunological response of a population from the Caribbean region of Colombia infected with the chikungunya virus JO - Revista Colombiana de Reumatología (English Edition) T2 - AU - Jaller Raad,Juan AU - Segura Rosero,Ana AU - Vidal Martínez,Jecenia AU - Parody,Alexander AU - Jaller Raad,Rodolfo AU - Caballero Tovar,Dayana AU - Camargo López,Patricia AU - Giraldo Ramírez,Miguel AU - Blanco Magdaniel,Jorge AU - Andrade Celedón,Luis SN - 24444405 M3 - 10.1016/j.rcreue.2016.07.003 DO - 10.1016/j.rcreue.2016.07.003 UR - https://www.elsevier.es/en-revista-revista-colombiana-reumatologia-english-edition--474-articulo-immunological-response-population-from-caribbean-S2444440516300279 AB - IntroductionChikungunya virus infection has become a public health problem, due to its immediate effect on the health and quality of life of patients and their families, as well as complications in the medium and long term. Its necessary to determine immunological characteristics of this afection as an important step for the future development of strategies to reduce its incidence and aggressiveness. ObjectiveTo characterize immunologically a population from Colombian Caribbean with serologic and clinic diagnosis of chikungunya virus infection. Material and methodsA descriptive, longitudinal, and prospective study was conducted on in 109 patients with a clinical diagnosis and serological confirmation of chikungunya virus infection and attended in the emergency department of the Fundación Hospital Universitario Metropolitano and the Orthopaedic and Rheumatology Centre. Immunoglobulin G or M type antibodies against Chikungunya virus were determined in a peripheral blood sample using immuno-enzymatic serological and immunological test in order to diagnose rheumatic diseases. ResultsTests were positive for immunoglobulin G type antibodies against chikungunya virus in all of the 109 patients. The results for anti-cyclic citrullinated peptide antibodies, rheumatoid factor, antinuclear, and anti-DNA antibodies were negative in almost all of the 109 patients. ConclusionPatients were not in a viral replication process that characterizes the acute phase of the disease. There were no positive results in laboratory test related to rheumatic diseases. High concentrations of certain pro-inflammatory interleukins were found in patients, and the clinical manifestations in these, suggest an inflammatory joint process with severe arthralgia that can mimic the symptoms of a rheumatic disease. ER -