TY - JOUR T1 - Relevance of dynamic studies with magnetic resonance enterography in Crohn's disease JO - Gastroenterología y Hepatología (English Edition) T2 - AU - Pous,Salvador AU - Frasson,Matteo AU - Jiménez,Raquel AU - Pamiés,José AU - Puchades,Icíar AU - Llavador,Margarita AU - García-Granero,Eduardo AU - Nos,Pilar SN - 24443824 M3 - 10.1016/j.gastre.2019.11.007 DO - 10.1016/j.gastre.2019.11.007 UR - https://www.elsevier.es/en-revista-gastroenterologia-hepatologia-english-edition--382-articulo-relevance-dynamic-studies-with-magnetic-S2444382420300444 AB - IntroductionA proper quantification of the inflammatory activity in Crohn's disease (CD) lesions is needed to establish the appropriate management for each patient. The aim of this study is to evaluate the inflammatory activity of affected segments in small bowel lesions using dynamic studies of magnetic resonance enterography (MRE) in patients undergoing surgery, and their correlation with the level of inflammation and histological fibrosis of the surgical piece. MethodsA prospective, consecutive, observational, clinical study was conducted that included all the patients with small bowel CD that underwent surgery in this center between March 2011 and September 2013. Diagnosis was established according to Lennard–Jones criteria and the Montreal classification. All the patients underwent MRE within three months before surgery, using a routine protocol involving Liver Acquisition with Volume Acceleration-Extended Volume (LAVA-XV) sequence for the dynamic studies before intravenous administering of gadolinium and 30, 70, 120, and 420s after administering this. The results allowed the designing of graphics with different uptake patterns. The Chiorean classification was used in the histological analysis, as well as a modified version published previously by this study group. ResultsA total of 28 patients with 47 lesions were analyzed. There was a significant correlation between both curve patterns, including the modified Chiorean classification (P<0.0001) as well as the level of inflammation (P<0.0001) and fibrosis (P<0.002). Inflammatory patterns of dynamic studies are related to histological findings with 80.9% accuracy (sensitivity=75.7%; specificity=100%). ConclusionThere is a high correlation between dynamic enhancement studies and the level of inflammatory activity. MRE is a suitable tool to differentiate between inflammatory and fibrotic lesions, making it useful to decide the appropriate management of each patient. ER -