TY - JOUR T1 - Hepatic angiosarcoma and liver transplantation: case report and literature review JO - Cirugía y Cirujanos (English Edition) T2 - AU - Huerta-Orozco,Lorena Denisse AU - Leonher-Ruezga,Karla Lisseth AU - Ramírez-González,Luis Ricardo AU - Hermosillo-Sandoval,José Manuel AU - Sandoval-Alvarado,José de Jesús AU - Morán-Galaviz,Rubén Eduardo SN - 24440507 M3 - 10.1016/j.circen.2015.11.016 DO - 10.1016/j.circen.2015.11.016 UR - https://www.elsevier.es/en-revista-cirugia-cirujanos-english-edition--237-articulo-hepatic-angiosarcoma-liver-transplantation-case-S2444050715001436 AB - BackgroundHepatic angiosarcoma is a rare vascular malignancy that accounts for 2% of all hepatic primary tumours. The diagnosis is difficult, especially if the patient does not have history of exposure to carcinogens, which are considered as risk factors. The diagnosis is made by histopathology, but in a considerable percentage it can only be accomplished by autopsy. The performing of fine needle aspiration biopsy can lead to bleeding, with limitations in its use. Clinical caseA 41 year-old male, with no history of exposure to carcinogens, who developed abdominal pain secondary to a haemoperitoneum due to tumour rupture, was diagnosed by imaging methods with a giant cavernous hepatic haemangioma. He was initially treated with embolisation, and later with a liver transplant. After six months he developed haemoptysis secondary to lung metastasis. The autopsy reported metastatic hepatic angiosarcoma. DiscussionThis condition has been related to carcinogen exposure, with malignant transformation from a benign vascular neoplasia being proposed as a hypothesis. The differential diagnosis can be achieved with imaging studies such as CT scan, and the definitive diagnosis is made by histopathology with immunohistochemistry tests, with 35–100% being made in the autopsy. ConclusionHepatic angiosarcoma is a malignant vascular neoplasia, the potential curative option is surgery with tumour free margins. Liver transplantation remains controversial because of its poor prognosis in the short term. ER -