TY - JOUR T1 - Encephalitis as a neurological manifestation of COVID-19 JO - Medicina Clínica (English Edition) T2 - AU - Lozano Gómez,Herminia AU - Pascual Bielsa,Ana AU - Abansés Moreno,Paula AU - Luque Gómez,María Pilar AU - Matute Guerrero,Almudena AU - Araiz Burdio,Juan José SN - 23870206 M3 - 10.1016/j.medcle.2021.07.001 DO - 10.1016/j.medcle.2021.07.001 UR - https://www.elsevier.es/en-revista-medicina-clinica-english-edition--462-articulo-encephalitis-as-neurological-manifestation-covid-19-S2387020621003478 AB - IntroductionIn the context of the global COVID-19 pandemic, the different clinical manifestations of this infection pose a challenge for healthcare professionals. Respiratory involvement, the main symptom of SARS-CoV-2 infection, means that other manifestations, such as neurological, take a back seat, with the consequent delay in diagnosis and treatment. Material and methodsAll COVID-19 patients admitted with neurological symptoms or diagnosed with encephalitis since March 2020 in a tertiary hospital in Zaragoza, Spain. ResultsTwo patients with COVID-19 infection confirmed by nasopharyngeal PCR and whose clinical picture consisted of neurological alterations compatible with encephalitis. Cerebrospinal fluid (CSF) microbiology was negative for bacteria and viruses, including SARS-CoV-2 but, given the clinical suspicion of encephalitis due to the latter, antiviral treatment with immunoglobulins and plasmapheresis was started early. Despite this, the evolution was not satisfactory. ConclusionsCOVID-19 encephalitis is a recently described clinical entity, whose pathophysiology is still unknown and no treatment with clinical evidence is available to date. ER -