TY - JOUR T1 - Evaluation of diffuse large B-cell lymphoma patients with 64-slice multidetector computed tomography versus 18FDG positron emission tomography/computed tomography in initial staging and restaging after treatment JO - Medicina Clínica (English Edition) T2 - AU - Gómez León,Nieves AU - Vega,Gema AU - Rodríguez-Vigil Junco,Beatriz AU - Suevos Ballesteros,Carlos SN - 23870206 M3 - 10.1016/j.medcle.2018.08.003 DO - 10.1016/j.medcle.2018.08.003 UR - https://www.elsevier.es/en-revista-medicina-clinica-english-edition--462-articulo-evaluation-diffuse-large-b-cell-lymphoma-S2387020618303292 AB - Background and objectivesTo prospectively compare the accuracy in initial staging and end-of-treatment restaging of diffuse large B-cell lymphoma (DLBCL) between 64-slice multidetector computed tomography (64MDCT) and 18FDG positron emission tomography/computed tomography (18FGD PET/CT) with intravenous contrast injection. Material and methodsRandomized and blind controlled clinical multicentric trial that included biopsy-proven DLBCL patients. Seventy-two patients from five different hospitals in the region of Madrid, Spain, were enrolled in the study between January 2012 and June 2015. Thirty-six were randomly allocated to 18FDG PET/TC and the other 36–64MDCT for initial staging and end-of-treatment restaging. A nuclear medicine physician and a radiologist independently analyzed 18FDG PET/TC images and reached an agreement post hoc. 64MDCT images were separately evaluated by a different radiologist. Every set of images was compared to the reference standard that included clinical data, complementary tests and follow-up. The study was approved by participating centres’ ethics committees and written informed consent was obtained from all the participants. ResultsA good agreement was observed between both diagnostic techniques and the reference standard in initial staging [18FDG PET/CT (k=0.5) and 64MDCT (k=0.6)], although only the 18FDG PET/TC showed a good agreement with the reference standard for the end-of-treatment restaging (k=0.7). ConclusionIn DLBCL, both 18FDG PET/TC and 64MDCT have shown good agreement with the reference standard in initial staging. Nevertheless, 18FDG PET/CT has shown to be superior to 64MDCT in end-of-treatment response assessment. ER -