TY - JOUR T1 - Hypertrophic cardiomyopathy JO - Medicina Clínica (English Edition) T2 - AU - Santos Mateo,Juan José AU - Sabater Molina,María AU - Gimeno Blanes,Juan Ramón SN - 23870206 M3 - 10.1016/j.medcle.2017.09.029 DO - 10.1016/j.medcle.2017.09.029 UR - https://www.elsevier.es/en-revista-medicina-clinica-english-edition--462-articulo-hypertrophic-cardiomyopathy-S238702061830127X AB - Hypertrophic cardiomyopathy is the most common inherited cardiovascular disease. It is characterized by increased ventricular wall thickness and is highly complex due to its heterogeneous clinical presentation, several phenotypes, large number of associated causal mutations and broad spectrum of complications. It is caused by mutations in sarcomeric proteins, which are identified in up to 60% of cases of the disease.Clinical manifestations of hypertrophic cardiomyopathy include shortness of breath, chest pain, palpitations and syncope, which are related to the onset of diastolic dysfunction, left ventricular outflow tract obstruction, ischemia, atrial fibrillation and abnormal vascular responses. It is associated with an increased risk of sudden cardiac death, heart failure and thromboembolic events. In this article, we discuss the diagnostic and therapeutic aspects of this disease. ER -