TY - JOUR T1 - The rs4285184 polymorphism of the MGAT1 gene as a risk factor for obesity in the Mexican population JO - Medicina Clínica (English Edition) T2 - AU - Tapia-Rivera,José C. AU - Baltazar-Rodríguez,Luz M. AU - Cárdenas-Rojas,Martha I. AU - Álvarez,Alan AU - Bustos-Saldaña,Rafael AU - Delgado-Enciso,Iván AU - Valdez-Velázquez,Laura L. AU - Guzmán-Esquivel,José AU - Ramírez-Flores,Mario SN - 23870206 M3 - 10.1016/j.medcle.2017.02.011 DO - 10.1016/j.medcle.2017.02.011 UR - https://www.elsevier.es/en-revista-medicina-clinica-english-edition--462-articulo-the-rs4285184-polymorphism-mgat1-gene-S2387020617301183 AB - Background and objectiveObesity is a factor that contributes to the morbidity of certain diseases and to worldwide mortality. MGAT1 is a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides and its polymorphisms are possibly involved in the etiology of obesity. We investigated the association of the rs4285184 polymorphism of the MGAT1 gene with obesity in adults in the State of Colima, Mexico. MethodsA case–control study was conducted that included 244 subjects. All of them were grouped according to their percentage of body fat, determined through bioelectrical impedance, and they were genotyped for the rs4285184 polymorphism of the MGAT1 gene through PCR-RFLP. The results were analyzed for their association with the percentage of body fat. ResultsThe G allele had a frequency of 49.19 and 38.75% for the cases and controls, respectively (P=.020) (OR 1.53; 95% CI 1.068–2.193). The frequency of the A/G+G/G genotype was 75% in the obese patients, which was significantly higher compared with the 57.5% of the control group (P=.004) (OR 2.217; 95% CI 1.287–3.821). ConclusionsThe presence of the rs4285184 polymorphism of the MGAT1 gene increased the risk for developing body fat associated with obesity in the Mexican population. ER -