TY - JOUR T1 - Experimental models of demyelination and remyelination JO - Neurología (English Edition) T2 - AU - Torre-Fuentes,L. AU - Moreno-Jiménez,L. AU - Pytel,V. AU - Matías-Guiu,J.A. AU - Gómez-Pinedo,U. AU - Matías-Guiu,J. SN - 21735808 M3 - 10.1016/j.nrleng.2019.03.007 DO - 10.1016/j.nrleng.2019.03.007 UR - https://www.elsevier.es/en-revista-neurologia-english-edition--495-articulo-experimental-models-demyelination-remyelination-S2173580819300586 AB - IntroductionExperimental animal models constitute a useful tool to deepen our knowledge of central nervous system disorders. In the case of multiple sclerosis, however, there is no such specific model able to provide an overview of the disease; multiple models covering the different pathophysiological features of the disease are therefore necessary. DevelopmentWe reviewed the different in vitro and in vivo experimental models used in multiple sclerosis research. Concerning in vitro models, we analysed cell cultures and slice models. As for in vivo models, we examined such models of autoimmunity and inflammation as experimental allergic encephalitis in different animals and virus-induced demyelinating diseases. Furthermore, we analysed models of demyelination and remyelination, including chemical lesions caused by cuprizone, lysolecithin, and ethidium bromide; zebrafish; and transgenic models. ConclusionsExperimental models provide a deeper understanding of the different pathogenic mechanisms involved in multiple sclerosis. Choosing one model or another depends on the specific aims of the study. ER -