TY - JOUR T1 - Current concepts on the pathophysiology of idiopathic chronic adult hydrocephalus: Are we facing another neurodegenerative disease? JO - Neurología (English Edition) T2 - AU - Martín-Láez,R. AU - Valle-San Román,N. AU - Rodríguez-Rodríguez,E.M. AU - Marco-de Lucas,E. AU - Berciano Blanco,J.A. AU - Vázquez-Barquero,A. SN - 21735808 M3 - 10.1016/j.nrleng.2016.03.013 DO - 10.1016/j.nrleng.2016.03.013 UR - https://www.elsevier.es/en-revista-neurologia-english-edition--495-articulo-current-concepts-on-pathophysiology-idiopathic-S217358081830035X AB - IntroductionSince its description five decades ago, the pathophysiology of idiopathic chronic adult hydrocephalus (iCAH) has been traditionally related to the effect that ventricular dilatation exerts on the structures surrounding the ventricular system. However, altered cerebral blood flow, especially a reduction in the CSF turnover rate, are starting to be considered the main pathophysiological elements of this disease. DevelopmentCompression of the pyramidal tract, the frontostriatal and frontoreticular circuits, and the paraventricular fibres of the superior longitudinal fasciculus have all been reported in iCAH. At the level of the corpus callosum, gliosis replaces a number of commissural tracts. Cerebral blood flow is also altered, showing a periventricular watershed region limited by the subependymal arteries and the perforating branches of the major arteries of the anterior cerebral circulation. The CSF turnover rate is decreased by 75%, leading to the reduced clearance of neurotoxins and the interruption of neuroendocrine and paracrine signalling in the CSF. ConclusionsiCAH presents as a complex nosological entity, in which the effects of subcortical microangiopathy and reduced CSF turnover play a key role. According to its pathophysiology, it is simpler to think of iCAH more as a neurodegenerative disease, such as Alzheimer disease or Binswanger disease than as the classical concept of hydrocephalus. ER -