TY - JOUR T1 - Epigenetic changes in neurology: DNA methylation in multiple sclerosis JO - NeurologĂ­a (English Edition) T2 - AU - Iridoy Zulet,M. AU - Pulido Fontes,L. AU - Ayuso Blanco,T. AU - Lacruz Bescos,F. AU - Mendioroz Iriarte,M. SN - 21735808 M3 - 10.1016/j.nrleng.2015.03.020 DO - 10.1016/j.nrleng.2015.03.020 UR - https://www.elsevier.es/en-revista-neurologia-english-edition--495-articulo-epigenetic-changes-in-neurology-dna-S2173580817300986 AB - IntroductionEpigenetics is defined as the study of the mechanisms that regulate gene expression without altering the underlying DNA sequence. The best known is DNA methylation. Multiple sclerosis (MS) is a disease with no entirely known aetiology, in which it is stated that the involvement of environmental factors on people with a genetic predisposition, may be key to the development of the disease. It is at this intersection between genetic predisposition and environmental factors where DNA methylation may play a pathogenic role. DevelopmentA literature review of the effects of environmental risk factors for the development of MS can have on the different epigenetic mechanisms as well as the implication that such changes have on the development of the disease. ConclusionKnowledge of epigenetic modifications involved in the pathogenesis of MS, opens a new avenue of research for identification of potential biomarkers, as well as finding new therapeutic targets. ER -