TY - JOUR T1 - Analysis of macular and nerve fibre layer thickness in multiple sclerosis patients according to severity level and optic neuritis episodes JO - Neurología (English Edition) T2 - AU - Soler García,A. AU - Padilla Parrado,F. AU - Figueroa-Ortiz,L.C. AU - González Gómez,A. AU - García-Ben,A. AU - García-Ben,E. AU - García-Campos,J.M. SN - 21735808 M3 - 10.1016/j.nrleng.2014.09.001 DO - 10.1016/j.nrleng.2014.09.001 UR - https://www.elsevier.es/en-revista-neurologia-english-edition--495-articulo-analysis-macular-nerve-fibre-layer-S2173580816300402 AB - IntroductionQuantitative assessment of macular and nerve fibre layer thickness in multiple sclerosis patients with regard to expanded disability status scale (EDSS) and presence or absence of previous optic neuritis episodes. MethodsWe recruited 62 patients with multiple sclerosis (53 relapsing-remitting and 9 secondary-progressive) and 12 disease-free controls. All patients underwent an ophthalmological examination, including quantitative analysis of the nerve fibre layer and macular thickness using optical coherence tomography. Patients were classified according to EDSS as A (lower than 1.5), B (between 1.5 and 3.5), and C (above 3.5). ResultsMean nerve fibre layer thickness in control, A, B, and C groups was 103.35±12.62, 99.04±14.35, 93.59±15.41, and 87.36±18.75μm respectively, with statistically significant differences (P<.05). In patients with no history of optic neuritis, history of episodes in the last 3 to 6 months, or history longer than 6 months, mean nerve fibre layer thickness was 99.25±13.71, 93.92±13.30 and 80.07±15.91μm respectively; differences were significant (P<.05). Mean macular thickness in control, A, B, and C groups was 220.01±12.07, 217.78±20.02, 217.68±20.77, and 219.04±24.26μm respectively. Differences were not statistically significant. ConclusionsThe mean retinal nerve fibre layer thickness in multiple sclerosis patients is related to the EDSS level. Patients with previous optic neuritis episodes have a thinner retinal nerve fibre layer than patients with no history of these episodes. Mean macular thickness is not correlated to EDSS level. ER -