TY - JOUR T1 - HaNDL syndrome: Correlation between focal deficits topography and EEG or SPECT abnormalities in a series of 5 new cases JO - Neurología (English Edition) T2 - AU - Barón,J. AU - Mulero,P. AU - Pedraza,M.I. AU - Gamazo,C. AU - de la Cruz,C. AU - Ruiz,M. AU - Ayuso,M. AU - Cebrián,M.C. AU - García-Talavera,P. AU - Marco,J. AU - Guerrero,A.L. SN - 21735808 M3 - 10.1016/j.nrleng.2015.03.010 DO - 10.1016/j.nrleng.2015.03.010 UR - https://www.elsevier.es/en-revista-neurologia-english-edition--495-articulo-handl-syndrome-correlation-between-focal-S2173580816300323 AB - IntroductionTransient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) is characterised by migraine-like headache episodes accompanied by neurological deficits consisting of motor, sensory, or aphasic symptoms. Electroencephalogram (EEG) and single photon emission computed tomography (SPECT) may show focal abnormalities that correspond to the neurological deficits. We aim to evaluate the correlation between focal deficit topography and EEG or SPECT abnormalities in 5 new cases. PatientsWe retrospectively reviewed patients attended in a tertiary hospital (January 2010-May 2014) and identified 5 patients (3 men, 2 women) with a mean age of 30.6±7.7 (21-39) years. They presented 3.4±2.6 episodes of headache (range, 2-8) of moderate to severe intensity and transient neurological deficits over a maximum of 5 weeks. Pleocytosis was detected in CSF in all cases (70 to 312cells/mm3, 96.5-100% lymphocytes) with negative results from aetiological studies. ResultsAt least one EEG was performed in 4 patients and SPECT in 3 patients. Patient 1: 8 episodes; 4 left hemisphere, 3 right hemisphere, and 1 brainstem; 2 EEGs showing left temporal and bilateral temporal slowing; normal SPECT. Patient 2: 2 episodes, left hemisphere and right hemisphere; SPECT showed decreased left temporal blood flow. Patient 3: 3 left hemisphere deficits; EEG with bilateral frontal and temporal slowing. Patient 4: 2 episodes with right parieto-occipital topography and right frontal slowing in EEG. Patient 5: 2 episodes, right hemisphere and left hemisphere, EEG with right temporal slowing; normal SPECT. ConclusionThe neurological deficits accompanying headache in HaNDL demonstrate marked clinical heterogeneity. SPECT abnormalities and most of all EEG abnormalities were not uncommon in our series and they did not always correlate to the topography of focal déficits. ER -