TY - JOUR T1 - Retinal neurodegeneration in patients with type 2 diabetes mellitus without diabetic retinopathy JO - Archivos de la Sociedad Española de Oftalmología (English Edition) T2 - AU - Ciprés,M. AU - Satue,M. AU - Melchor,I. AU - Gil-Arribas,L. AU - Vilades,E. AU - Garcia-Martin,E. SN - 21735794 M3 - 10.1016/j.oftale.2022.02.009 DO - 10.1016/j.oftale.2022.02.009 UR - https://www.elsevier.es/en-revista-archivos-sociedad-espanola-oftalmologia-english-496-articulo-retinal-neurodegeneration-in-patients-with-S217357942200038X AB - In diabetes mellitus (DM) patients retinal complications were typically considered part of a vascular process. Recent research suggests that retinal degeneration in DM might also be caused by a neuropathy that could precede microvascular alterations. The present work reviews the currently available bibliography about neurodegeneration in patients with type 2 DM (DM2) without diabetic retinopathy (DR).In patients with non-severe, early DM2 without DR and good metabolic control visual function parameters show early abnormalities that precede clinical DR (in which we diagnose with a conventional ophthalmological examination). Using optical coherence tomography (OCT) technology, a reduction in macular and peripapillary thickness has been observed in different studies. Recent researches suggest that systemic complications (especially ischaemia) and a possible microvascular alteration eventually contributes to retinal neurodegeneration, which opens the door to new studies that include new techniques for evaluating the microvascularization of the retinal layers. ER -