TY - JOUR T1 - Infections related to healthcare in patients hospitalized in a Urology service: Resistance patterns and adequacy of empirical antibiotic treatment as a prognostic factor JO - Actas Urológicas Españolas (English Edition) T2 - AU - Benítez-Sala,R. AU - Medina-Polo,J. AU - Justo-Quintas,J. AU - Gil-Moradillo,J. AU - Pérez-Cadavid,S. AU - Arrébola-Pajares,A. AU - Sopeña-Sutil,R. AU - Lara-Isla,A. AU - Alonso-Isa,M. AU - González-Padilla,D.A. AU - García-Rojo,E. AU - Miranda-Utrera,N. AU - Aguilar-Gisbert,L. AU - Tejido-Sánchez,Á. SN - 21735786 M3 - 10.1016/j.acuroe.2018.08.002 DO - 10.1016/j.acuroe.2018.08.002 UR - https://www.elsevier.es/en-revista-actas-urologicas-espanolas-english-392-articulo-infections-related-healthcare-in-patients-S2173578619300241 AB - ObjectivesTo evaluate the suitability of empirical antibiotic therapy in HAIs and the antibiotic resistance patterns of the responsible microorganisms, as well as the incidence of mortality and risk factors involved. MethodA prospective observational study was carried out on patients of both sexes older than 16years, admitted by any urological process during a period of 4years. The incidence and characteristics of HAIs, as well as the causative organism and its resistance, the initial empirical antibiotic therapy and its modification, if required, and mortality rates are analyzed. ResultsOut of 6546 patients, 6.3% suffered HAIs, 70.5% corresponding to urinary tract infection and 22.1% to infection of the surgical wound. E.coli, Enterococcus spp., Klebsiella spp. y P.aeruginosa were the most frequently implicated (25.1%, 17.5%, 13.5% and 12.3%, respectively). E.coli and Klebsiella spp. were producers of extended-spectrum beta-lactamases (ESBL) in 24.7% and 47.8%, respectively. 4.3% of Klebsiella and 33.3% of Pseudomonas were carbapenems-resistant. The overall resistance to quinolones was approximately 50%. The most commonly used antibiotics for empirical therapy were cephalosporins of 3rd and 4th generation (33.6%) and carbapenems (28.2%). An overall rate of adequacy of empirical antibiotic therapy of 82.9% was obtained. The mortality rate in patients with HAIs was 2.2%, compared with 0.3% in patients without infection. In a multivariate analysis, the variables associated with the highest mortality risk were the isolation of ESBL-producing enterobacteria and the inadequate empirical antibiotic treatment. ConclusionsThe selection of empirical antibiotic therapy was quite accurate. An increase in HAIs by multiresistant microorganisms, such as ESBL Enterobacteria or multiresistant P.aeruginosa is being observed. The mortality risk increases with inadequate initial empirical antibiotic therapy or when the responsible microorganism is an ESBL enterobacteria. ER -