TY - JOUR T1 - Urinary tract infections and their prevention JO - Actas Urológicas Españolas (English Edition) T2 - AU - González-Chamorro,F. AU - Palacios,R. AU - Alcover,J. AU - Campos,J. AU - Borrego,F. AU - Dámaso,D. SN - 21735786 M3 - 10.1016/j.acuroe.2011.05.001 DO - 10.1016/j.acuroe.2011.05.001 UR - https://www.elsevier.es/en-revista-actas-urologicas-espanolas-english-392-articulo-urinary-tract-infections-their-prevention-S2173578612000248 AB - ContextThis article reviews diverse aspects of the prevention of urinary tract infections, including confirmation of the diagnosis, application of hygiene and dietary measures, antibacterial prophylaxis (preferably consisting of a single nocturnal oral dose per day of an antibiotic or drug with high urinary excretion and good tolerance), and administration of vaccines made with Escherichia coli and other Gram-negative bacilli, consisting of immunostimulating fractions of E. coli strains or E. coli type-1 fimbriae administered through the parenteral or oral route. ObjectiveWe aimed to review the new preventive measures against urinary tract infections. Acquisition and synthesis of evidenceWe reviewed various microbiological aspects, as well as the physiopathology and virulence factors of uropathogenic E. coli strains expressing type-1 and P fimbriae. The association between blood groups and urinary tract infections in blood group antigen-secretors and nonsecretors was analyzed. ConclusionsNew preventive measures against urinary tract infection consist of the use of phenol-inactivated vaccines administered via the mucosal route, inhibitors of bacterial adherence and biofilm formation, and cyclic adenosine monophosphate stimulators, especially in women aged between puberty and menopause, who show the highest incidence of these infections. ER -