TY - JOUR T1 - Expression of E-cadherin and β-catenin in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas JO - Acta Otorrinolaringológica Española T2 - AU - García-Cabo,Patricia AU - García-Pedrero,Juana María AU - Villaronga,M. Ángeles AU - Hermida-Prado,Francisco AU - Granda-Díaz,Rocío AU - Allonca,Eva AU - López,Fernando AU - Rodrigo,Juan Pablo SN - 21735735 M3 - 10.1016/j.otoeng.2019.12.003 DO - 10.1016/j.otoeng.2019.12.003 UR - https://www.elsevier.es/en-revista-acta-otorrinolaringologica-espanola-402-articulo-expression-e-cadherin-catenin-in-laryngeal-S2173573520301034 AB - Introduction and objectivesdysfunction of the E-cadherin/catenin complex is directly related to carcinogenesis and metastases development.The aim of this paper is to investigate the prognostic significance of E-cadherin and β-catenin expression in surgically treated laryngeal and hypopharyngeal squamous cell carcinomas. Material and methodsTumour tissue samples were obtained from 133 consecutive patients with squamous cell carcinomas of the head and neck: 68 of the larynx and 65 hypopharyngeal carcinomas, who underwent surgical treatment in our hospital between 2000 and 2005.E-cadherin and β-catenin expression was analysed by immunohistochemistry, quantifying the percentage of stained cells and the intensity of staining. ResultsE-cadherin and β-catenin expression was evaluable in 59 laryngeal carcinomas and in 58 cases of hypopharyngeal carcinomas.In the laryngeal tumours, a significant association was found between the low expression of membrane β-catenin with T4 tumours and tumour recurrence. In the hypopharynx there was a significant association between positive expression of nuclear β-catenin and poor histological differentiation (P = .02). In the multivariate analysis, only the presence of lymph node metastases was an independent predictive factor of decreased disease-specific survival in laryngeal squamous cell carcinomas. ConclusionsThe expression of E-cadherin and β-catenin does not show prognostic significance in laryngeal and hypopharyngeal squamous cell carcinomas over the TNM classification. ER -