TY - JOUR T1 - Salivary Pepsin Test: Useful and Simple Tool for the Laryngopharyngeal Reflux Diagnosis JO - Acta Otorrinolaringológica Española T2 - AU - Barona-Lleó,Luz AU - Duval,Claudia AU - Barona-de Guzmán,Rafael SN - 21735735 M3 - 10.1016/j.otoeng.2017.03.002 DO - 10.1016/j.otoeng.2017.03.002 UR - https://www.elsevier.es/en-revista-acta-otorrinolaringologica-espanola-402-articulo-salivary-pepsin-test-useful-simple-S2173573518300140 AB - Introduction and objectivesLaryngopharyngeal reflux (LPR) is a disease characterized by the presence of symptoms, signs and tissue damage caused by retrograde flow of gastric contents to the upper aerodigestive tract. It represents up to 10% of otolaryngology consultations.The aim of the study is to describe the findings obtained by applying the salivary pepsin test (PEP-test) in a sample of patients with the clinical suspicion of LPR. Material and methodsOur descriptive clinical study included 142 subjects with symptoms suggestive of LPR and a score above 13 on the RSI scale. The subjects underwent laryngeal endoscopy to rule out other pathologies that could justify the symptoms and the salivary pepsin test (PEP-test). The latter was carried out on fasting subjects and a second test one hour after eating, only on those with negative results. ResultsThe results obtained in the tests performed on the 142 patients included in the study were: 105 (73.94%) presented positive results in some of the salivary pepsin tests and the results of both tests were negative in 37 subjects (26.06%). ConclusionThe salivary pepsin test is a simple, low-cost, non-invasive and easily repeatable tool which could minimize empirical treatments and invasive tests for LPR diagnosis, although further research is needed for its validation. ER -