TY - JOUR T1 - Familial Clustering of Nasopharyngeal Carcinoma in Non-Endemic Area. Report of Three Families JO - Acta Otorrinolaringológica Española T2 - AU - Paredes-Durán,Leydy Mallerling AU - del Barco-Morillo,Elvira AU - Baldeón-Conde,María Jesús AU - Medina-Valdivieso,Soledad AU - Guillen-Sacoto,María Cecilia AU - Cruz-Hernández,Juan Jesús SN - 21735735 M3 - 10.1016/j.otoeng.2016.07.011 DO - 10.1016/j.otoeng.2016.07.011 UR - https://www.elsevier.es/en-revista-acta-otorrinolaringologica-espanola-402-articulo-familial-clustering-nasopharyngeal-carcinoma-in-S2173573517300443 AB - Nasopharyngeal carcinoma is the predominant tumour type arising in the nasopharynx. Its aetiology is multifactorial; racial and geographical distribution, EBV infection and environmental exposure to specific substances are considered risk factors.This condition is endemic in some Asian areas, where a genetic predisposition in its oncogenesis has been established. There is a strong susceptibility between nasopharyngeal carcinoma and HLA, where related specific haplotypes have been found.In areas where the incidence is low, there are few reported cases of families affected. We report 3 cases of families with nasopharyngeal carcinoma among siblings, in the non-Asian population, probably related to EBV infection. ER -