TY - JOUR T1 - Changes in arterial stiffness, carotid intima-media thickness, and epicardial fat after L-thyroxine replacement therapy in hypothyroidism JO - Endocrinología y Nutrición (English Edition) T2 - AU - del Busto-Mesa,Abdel AU - Cabrera-Rego,Julio Oscar AU - Carrero-Fernández,Lisván AU - Hernández-Roca,Cristina Victoria AU - González-Valdés,Jorge Luis AU - de la Rosa-Pazos,José Eduardo SN - 21735093 M3 - 10.1016/j.endoen.2015.06.001 DO - 10.1016/j.endoen.2015.06.001 UR - https://www.elsevier.es/en-revista-endocrinologia-nutricion-english-edition--412-articulo-changes-in-arterial-stiffness-carotid-S2173509315000793 AB - ObjectiveTo assess the relationship between primary hypothyroidism and subclinical atherosclerosis and its potential changes with L-thyroxine replacement therapy. MethodsA prospective cohort study including 101 patients with primary hypothyroidism and 101 euthyroid patients as controls was conducted from July 2011 to December 2013. Clinical, anthropometrical, biochemical, and ultrasonographic parameters were assessed at baseline and after one year of L-thyroxine replacement therapy. ResultsAt baseline, hypothyroid patients had significantly greater values of blood pressure, total cholesterol, VLDL cholesterol, left ventricular mass, epicardial fat, and carotid intima-media thickness as compared to controls. Total cholesterol, VLDL cholesterol, ventricular diastolic function, epicardial fat, carotid intima-media thickness, carotid local pulse wave velocity, pressure strain elastic modulus, and β arterial stiffness index showed a significant and positive correlation with TSH levels. After one year of replacement therapy, patients with hypothyroidism showed changes in total cholesterol, VLDL cholesterol, TSH, carotid intima-media thickness, and arterial stiffness parameters. ConclusionsPrimary hypothyroidism is characterized by an increased cardiovascular risk. In these patients, L-thyroxine replacement therapy for one year is related to decreased dyslipidemia and improvement in markers of subclinical carotid atherosclerosis. ER -