TY - JOUR T1 - Thermolabile Drugs. Operating Procedure in the Event of Cold Chain Failure JO - Farmacia Hospitalaria (English Edition) T2 - AU - Periáñez Parraga,L. AU - Gómez-Lobón,A. AU - Gamón Runnenberg,I. AU - Seco Melantuche,R. AU - Delgado Sánchez,O. AU - Puigventós Latorre,F. SN - 21735085 M3 - 10.1016/j.farmae.2010.07.001 DO - 10.1016/j.farmae.2010.07.001 UR - https://www.elsevier.es/en-revista-farmacia-hospitalaria-english-edition--221-articulo-thermolabile-drugs-operating-procedure-in-S2173508511000141 AB - ObjectiveTo establish a standard operating procedure in the event of cold chain failure. MethodWe selected thermolabile drugs included in the hospital's pharmaceutical guide. We performed a review of the available literature, classifying each drug into a given category with an intervention protocol for each one. ResultsWe reviewed 254 drugs (162 active ingredients). Categories were: A (stable ≥28days at 25°C): 65 drugs; B (≥7days at 25°C): 47 drugs; C (≥48h at 25°C): 30 drugs; D (<48h at 25°C): 47 drugs; E (unstable >8°C): 12 drugs; F (batch-dependent) 22 drugs. Thirty-one drugs were not classified into any category.The intervention protocol consisted of establishing a system to monitor the products concerned, and discarding or returning them to the laboratory if they were to exceed the time or temperature limit indicated for each category. DiscussionThe aim of this study is to make intervention quicker in the event of cold chain failure. ER -