TY - JOUR T1 - Neuronal migration, apoptosis and bipolar disorder JO - Revista de Psiquiatría y Salud Mental (English Edition) T2 - AU - Uribe,Ezequiel AU - Wix,Richard SN - 21735050 M3 - 10.1016/j.rpsmen.2011.11.003 DO - 10.1016/j.rpsmen.2011.11.003 UR - https://www.elsevier.es/en-revista-revista-psiquiatria-salud-mental-486-articulo-neuronal-migration-apoptosis-bipolar-disorder-S2173505012000386 AB - Bipolar disorder, like the majority of psychiatric disorders, is considered a neuro-development disease. There is an increased rate of neuronal birth and death during this development period. In the particular case of the processes that determine neuronal death, it is known that those neurons that establish connections have to be removed from the central nervous system. There is a deficit of GABAergic interneurons in the cerebral cortex in bipolar disorder, accompanied by overexpression of proapoptic genes. There is also an alteration in the expression of molecules that mediate in the migration of these neurons and their inclusion in functional synapsis during the foetal stage. The role of these molecules in the neuronal death pathways by apoptosis will be reviewed here in an attempt to establish biological hypotheses of the genesis of bipolar disorder. ER -