TY - JOUR T1 - Hemodynamically unstable ductus arteriosus treated with paracetamol in a tertiary care hospital in the northeast of Mexico JO - Medicina Universitaria T2 - AU - Rodríguez-Balderrama,I. AU - Morales-Rodríguez,I.B. AU - Sánchez-Cortez,R.G. AU - Tijerina-Guajardo,M. SN - 16655796 M3 - 10.1016/j.rmu.2017.04.002 DO - 10.1016/j.rmu.2017.04.002 UR - https://www.elsevier.es/en-revista-medicina-universitaria-304-articulo-hemodynamically-unstable-ductus-arteriosus-treated-S1665579617300431 AB - IntroductionPatent ductus arteriosus (PDA) in premature infants after birth is associated with an increased risk of morbidity and mortality. Indomethacin or ibuprofen are the current treatments, with success rate of 70–85%, but also show severe side effects. ObjectiveTo demonstrate the success of intravenous paracetamol as a treatment for the hemodynamically unstable patient with ductus arteriosus closure, in a third level hospital in northeastern Mexico. Subjects and methodsWe performed a cross-sectional, observational retrospective study. All patients brought to our department between March 2013 and September 2014 were included. We also included files confirming PDA through the Yeh criteria and echocardiographic data before and after the patients took paracetamol. ResultsTwenty-four files were included in our study. 4 of them were unable to close their PDA, with paracetamol so they had to go to surgical closure. Success in closing PDA with paracetamol was 83%, and we found significant differences in the PDA measurements (2.5 [±0.8] vs. 0.8mm [±1.1] mm, P<0.001), the left atrium/aorta ratio, the right to left shunt, and ductus arteriosus/aorta ratio before and after treatment. Sepsis and bronchopulmonary dysplasia were found in 100% of patients who failed treatment, compared to 40 and 25% in the success group respectively. No side effects were present in any of the patients. ConclusionsThe use of paracetamol for ductus arteriosus closure could be effective, economical and with fewer side effects than current treatments. ER -