TY - JOUR T1 - Unusual case of plasmablastic Non-Hodgkin’s lymphoma located in the liver. First case reported in an AIDS patient JO - Annals of Hepatology T2 - AU - Metta,Humberto AU - Corti,Marcelo AU - Maranzana,Aldo AU - Schtirbu,Ricardo AU - Narbaitz,Marina AU - De Dios Soler,Marcela SN - 16652681 M3 - 10.1016/S1665-2681(19)31773-9 DO - 10.1016/S1665-2681(19)31773-9 UR - https://www.elsevier.es/en-revista-annals-hepatology-16-articulo-unusual-case-plasmablastic-non-hodgkins-lymphoma-S1665268119317739 AB - Plasmablastic lymphoma is a rare and a relatively new entity that was first described in the jaws and the oral cavity of HIV-AIDS patients. We report a case of plasmablastic lymphoma involving the liver in an AIDS patient. Plasmablastic lymphoma is considered a diffuse large B-cell lymphoma with a unique phenotype and predilection for the oral cavity. The case presented had a unique hepatic lesion, localized in the left lobe of the liver. Diagnosis was confirmed by hepatic biopsy guided by Computerized Tomography scan and histopathology. The smears showed a dense infiltrate composed by atypical lymphocytes with numerous plasmocytes expressing the plasma cell markers MUM-1 and CD138 and negative for the B-cell markers CD3, CD20 and CD45. Immunohistochemical and in situ hibridization revealed the Epstein-Barr virus genome in the atypical cells. Polymerase chain reaction was negative for HHV-8 RNA. ER -