TY - JOUR T1 - Gastroesophageal reflux in the patiens with asthma JO - Allergologia et Immunopathologia T2 - AU - Harmanci,E AU - Entok,E AU - Metintas,M AU - Vardareli,E AU - Elbek,O SN - 03010546 UR - https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-gastroesophageal-reflux-in-patiens-with-13020606 AB - Thirty one patients with asthma (mean age was 44.4 ± 10.7; range 18-63) were investigated for gastroesophageal reflux (GER). The patients were seperated into two groups according to presence of reflux and/or nocturnal symptoms. 13 patients had one of the reflux and/or nocturnal asthma symptoms (Group 1), whereas 18 patients had none of them (Group 2). To assess GER patients underwent to scintigraphy with Tc99m. GER was determined 4 of 13 patients in group 1 (30,7 %) and 1 of 18 patients in group 2 (5,5 %). There was significant difference between the group 1 and group 2 in that respect (p < 0,001). The patients with established GER (5 patients) were given Omeprazole (a proton pomp inhibitor) 40 mg daily for 4 weeks following a 2 week placebo period. The patients recorded their daily and nocturnal symptoms of asthma, additional salbutamol use, morning and evening peak expiratory flow rates (PEFR) measurements in a daily chart during placebo and omeprazole treatment without changing their antiasthma treatment. Their PEFR, FEV1 values, daily and nocturnal symtoms and additional beta agonist use did not changed after omeprazole treatment except one. But their reflux symtoms (heartburn and regurgitation) were improved. As a consequence, we suggested that asthmatics which have some complaints of reflux should be searched for GER. Not the respiratory functions but GER symptoms can be improved w ER -